PDGF R beta Protein, Cynomolgus (HEK293, His)

PDGF R beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PDGF R beta protein, expressed by HEK293, with C-His tag.

PDGF R beta, a tyrosine-protein kinase, serves as a cell-surface receptor for homodimeric PDGFB and PDGFD, as well as heterodimers formed by PDGFA and PDGFB. This receptor plays a crucial role in the intricate regulation of embryonic development, overseeing processes such as cell proliferation, survival, differentiation, chemotaxis, and migration. Particularly vital in blood vessel development, PDGF R beta facilitates the proliferation, migration, and recruitment of pericytes and smooth muscle cells to endothelial cells, contributing significantly to the formation and maintenance of blood vessels.

Cynomolgus

HEK293

C-8*His

A0A2K5TUS0 (L33-K531)

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Extracellular Domain

LVITPPGPELILNVSSTFVLTCSGSAPVVWERMSQELPQEMAKAQDNTFSSVLTLTNLTGLDTGEYFCTYNDSRGLEPDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDIALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWMYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGALQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPMLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDMQEVIVVPHSLPFK

Approximately 75-105 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.