PDGFRB Protein, Human (HEK293, Fc)

The PDGFRB Protein encodes a cell surface tyrosine kinase receptor that interacts with members of the platelet-derived growth factor family, known mitogens for cells of mesenchymal origin. The identity of the growth factor binding to a receptor monomer determines whether the functional receptor forms a homodimer (with PDGFB or PDGFD) or a heterodimer (with PDGFA and PDGFB). Essential for normal cardiovascular system development and the rearrangement of the actin cytoskeleton, this gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, with all three potentially implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, resulting in the fusion of this gene with that of the ETV6 gene, leads to chronic myeloproliferative disorder with eosinophilia. Broadly expressed, the PDGF R beta gene exhibits elevated levels in the gall bladder (RPKM 79.5), placenta (RPKM 61.0), and 21 other tissues, indicating its involvement in diverse physiological contexts across multiple organs.