Pentraxin 2/SAP Protein, Human (HEK293, His)
Based on 2 publication(s) in Google Scholar
Pentraxin 2/SAP protein, a member of the pentraxin family, promotes innate immunity by recognizing pathogens and promoting their clearance. This soluble pattern recognition receptor is involved in multiple inflammatory processes, including complement activation, opsonization, and immune response regulation. Pentraxin 2/SAP Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 2/SAP protein, expressed by HEK293 , with C-6*His labeled tag.
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- Species: Human
- Source: HEK293
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保管条件:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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生物活性
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Technical Parameters
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Product Properties
- ドキュメント
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生物活性
Pentraxin 2/SAP protein, a member of the pentraxin family, promotes innate immunity by recognizing pathogens and promoting their clearance. This soluble pattern recognition receptor is involved in multiple inflammatory processes, including complement activation, opsonization, and immune response regulation. Pentraxin 2/SAP Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 2/SAP protein, expressed by HEK293 , with C-6*His labeled tag.
CLIC2/XAP121 protein exhibits the capability to insert into membranes, forming chloride ion channels whose activity is pH-dependent. The process of membrane insertion appears to be regulated by redox conditions, occurring predominantly under oxidizing conditions. Notably, CLIC2/XAP121 plays a regulatory role in modulating RYR2 activity, ultimately inhibiting calcium influx. This protein functions as a monomer and engages in interactions with TRAPPC2 and RYR2, suggesting a potential role in intricate cellular processes.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. [Abstract]2025 Oct 2;188(20):5763-5784.e26. PMID: 40713952 -
J Am Chem Soc
FAP-Synergistic Organ-Targeted mRNA-LNP for Overcoming Delivery Barriers in Hepatic and Pulmonary Fibrosis. [Abstract]2026 Mar 11;148(9):9309-9327. PMID: 41731656
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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アクセッション番号
P02743 (H20-V223)
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遺伝子ID325 [NCBI]
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Molecular Construction
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N-term
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SAP (H20-V223)
Accession # P02743 -
6*His
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C-term
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Protein Length
Full Length of Mature Protein
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別名
Serum Amyloid P-Component; SAP; 9.5S Alpha-1-Glycoprotein; APCS; PTX2
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AA Sequence
HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV
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Predicted Molecular Mass
24.2 kDa
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分子量
Approximately 30 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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純度
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
ドキュメント
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データシート (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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