PSMB6 Protein, Mouse (His)

PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome. This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins. PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E. coli , with N-His labeled tag. The total length of PSMB6 Protein, Mouse (His) is 205 a.a., with molecular weight of ~24.2 kDa.

PSMB6, an integral component of the 20S core proteasome complex, takes part in the proteolytic degradation of the majority of intracellular proteins, contributing to essential cellular functions. Its association with two 19S regulatory particles results in the formation of the 26S proteasome, which actively engages in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome is crucial for maintaining protein homeostasis by eliminating misfolded or damaged proteins that could compromise cellular functions, as well as proteins that are no longer needed. Additionally, PSMB6 participates in ubiquitin-independent protein degradation when associated with PA200 or PA28 within the 20S proteasome, playing a pivotal role in processes such as spermatogenesis and the generation of MHC class I-presented antigenic peptides. Within the 20S core complex, PSMB6 exhibits peptidylglutamyl-hydrolyzing activity, also known as postacidic or caspase-like activity, wherein peptide bond hydrolysis occurs directly after acidic residues.

Mouse

E. coli

N-His

Q60692 (T34-P238)

19175  [NCBI]

Approximately 24.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.