PSMB6 Protein, Mouse (His)
PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome.This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins.PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E.coli , with N-His labeled tag.
- Species: Mouse
- Source: E. coli
-
Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome.This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins.PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E.coli , with N-His labeled tag.
PSMB6, an integral component of the 20S core proteasome complex, takes part in the proteolytic degradation of the majority of intracellular proteins, contributing to essential cellular functions. Its association with two 19S regulatory particles results in the formation of the 26S proteasome, which actively engages in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome is crucial for maintaining protein homeostasis by eliminating misfolded or damaged proteins that could compromise cellular functions, as well as proteins that are no longer needed. Additionally, PSMB6 participates in ubiquitin-independent protein degradation when associated with PA200 or PA28 within the 20S proteasome, playing a pivotal role in processes such as spermatogenesis and the generation of MHC class I-presented antigenic peptides. Within the 20S core complex, PSMB6 exhibits peptidylglutamyl-hydrolyzing activity, also known as postacidic or caspase-like activity, wherein peptide bond hydrolysis occurs directly after acidic residues.
Technical Parameters
-
Species Mouse
-
Source E. coli
-
Tag N-His
-
Accession
Q60692 (T34-P238)
-
Molecular Construction
-
N-term
-
His
-
PSMB6 (T34-P238)
Accession # Q60692 -
C-term
-
-
Protein Length
Full Length of Mature Protein
-
Synonyms
PSMB6; Macropain Delta Chain; Proteasome 20S Subunit Beta 6; Proteasome Subunit Y; DELTA; Beta-1; Y; LMPY; Proteasome (Prosome, Macropain) Subunit, Beta Type, 6; PSY Large Multifunctional Protease Y; Multicatalytic Endopeptidase Complex Delta Chain; Prote
-
AA Sequence
TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATLPPP
-
Predicted Molecular Mass
24.2 kDa
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
