RP105/CD180 Protein, Human (HEK293, His)

RP105/CD180 is a key mediator in B cells that cooperates with MD-1 and TLR4 to initiate the innate immune response against bacterial lipopolysaccharide (LPS). This cooperation activates NF-kappa-B, underscoring its role in key signaling pathways. RP105/CD180 Protein, Human (HEK293, His) is the recombinant human-derived RP105/CD180 protein, expressed by HEK293 , with C-His labeled tag. The total length of RP105/CD180 Protein, Human (HEK293, His) is 603 a.a., with molecular weight of 90-100 kDa.

The RP105/CD180 protein emerges as a key player in mediating the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells, likely through cooperation with MD-1 and TLR4. This collaborative effort leads to NF-kappa-B activation, underscoring its role in initiating crucial signaling pathways. Additionally, RP105/CD180 is implicated in the life/death decision of B-cells, indicating its involvement in critical cellular processes. The structural organization of RP105/CD180 involves the formation of an M-shaped tetramer, constituted by two CD180-LY86 heterodimers. These distinctive features highlight the multifaceted nature of RP105/CD180 in orchestrating immune responses and cellular decisions in B-cells. Further exploration is essential to unravel the specific molecular mechanisms through which RP105/CD180 contributes to the intricate dynamics of the innate immune system and its collaboration with MD-1 and TLR4 in response to bacterial LPS.

Human

HEK293

C-His

Q99467 (W24-G626)

4064  [NCBI]

90-100 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.