SDPR Protein, Mouse (His)
SDPR proteins complexly regulate caveolae biogenesis and morphology, inducing membrane curvature of specialized caveolae.Tissue-wise, it is critical for caveolae in lung and fat endothelial cells, but not in cardiac endothelial cells.SDPR Protein, Mouse (His) is the recombinant mouse-derived SDPR protein, expressed by E.coli , with N-His labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SDPR proteins complexly regulate caveolae biogenesis and morphology, inducing membrane curvature of specialized caveolae.Tissue-wise, it is critical for caveolae in lung and fat endothelial cells, but not in cardiac endothelial cells.SDPR Protein, Mouse (His) is the recombinant mouse-derived SDPR protein, expressed by E.coli , with N-His labeled tag.
Background
The SDPR protein is intricately involved in caveolar biogenesis and morphology, serving as a key regulator of caveolae structure by inducing membrane curvature within these specialized membrane invaginations. Its role in caveola formation exhibits tissue-specific characteristics, being essential for caveolae development in the lung and fat endothelia but not in the heart endothelia. In lung endothelial cells, SDPR acts as a negative regulator of the size or stability of CAVIN complexes. Additionally, it may play a role in targeting PRKCA to caveolae and forms a crucial component of the CAVIN complex alongside CAVIN1, CAVIN2, CAVIN3, and CAVIN4. SDPR's interactions with PRKCA, CAVIN4, CAVIN1, and CAV3 underscore its multifaceted involvement in caveolar dynamics, shedding light on its significance in the regulation of cellular membrane structures and associated signaling pathways.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-His
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Accession
Q63918 (G2-A180)
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Gene ID20324 [NCBI]
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Molecular Construction
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N-term
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His
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SDPR (G2-A180)
Accession # Q63918 -
C-term
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Protein Length
Partial
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Synonyms
CAVIN2; Serum Deprivation-Response Protein; Prev. SDPR; Serum Deprivation Response; Cavin-2; Serum Deprivation Response (Phosphatidylserine-Binding Protein); PS-P68; Serum Deprivation Response (Phosphatidylserine Binding Protein); SDR; Phosphatidylserine
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AA Sequence
GEDAAQAEKFQHPNTDMLQEKPSSPSPMPSSTPSPSLNLGSTEEAIRDNSQVNAVTVHTLLDKLVNMLDAVRENQHNMEQRQINLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVRERLERQCVQVKRLENNHAQLLRRNHFKVLIFQEESEIPASVFVKEPVPSAA
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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