SLC38A1 Protein, Human (HEK293, His, MBP, FLAG)
The SLC38A1 protein acts as an symporter, facilitating the pH-dependent cotransport of short-chain neutral amino acids and sodium ions across cell membranes. Crucially, it mediates astrocyte-derived glutamine transport to GABAergic interneurons, contributing to de novo GABA synthesis. SLC38A1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC38A1 protein, expressed by HEK293, with N-MBP, C-Flag, N-8*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
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Biological Activity
Description
The SLC38A1 protein acts as an symporter, facilitating the pH-dependent cotransport of short-chain neutral amino acids and sodium ions across cell membranes. Crucially, it mediates astrocyte-derived glutamine transport to GABAergic interneurons, contributing to de novo GABA synthesis. SLC38A1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC38A1 protein, expressed by HEK293, with N-MBP, C-Flag, N-8*His labeled tag.
Background
The SLC38A1 protein functions as a symporter, facilitating the cotransport of short-chain neutral amino acids and sodium ions across the cell membrane from the extracellular to the intracellular side. This electrogenic process is pH-dependent and driven by the electrochemical gradient of Na(+). Notably, SLC38A1 plays a crucial role in mediating the transport of astroglia-derived glutamine into GABAergic interneurons, contributing to the de novo synthesis of the neurotransmitter GABA. Additionally, it is implicated in amino acid transport in placental trophoblasts. The regulatory influence of SLC38A1 extends to synaptic plasticity, highlighting its involvement in fundamental cellular processes with implications for neurotransmitter synthesis and amino acid transport.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-8*His;C-Flag;N-Myc
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Accession
Q9H2H9 (M2-H487)
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Gene ID81539
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Molecular Construction
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N-term
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8*His-MBP
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SLC38A1 (M2-H487)
Accession # Q9H2H9 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
SLC38A1; Sodium-Coupled Neutral Amino Acid Symporter 1; Solute Carrier Family 38 Member 1; N-System Amino Acid Transporter 2; SNAT1; System A Amino Acid Transporter 1; ATA1; System N Amino Acid Transporter 1; NAT2; Amino Acid Transporter A1; SAT1; Solute Carrier Family 38, Member 1; Sodium-Coupled Neutral Amino Acid Transporter 1; Amino Acid Transporter System A1
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AA Sequence
MHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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