SPG21 Protein, Mouse (sf9, His)
Based on 1 Customer Validation
The SPG21 protein acts as a negative regulator in CD4-dependent T cell activation, suggesting a potential role in the regulation of immune responses. By interacting directly with CD4, it affects key components of the T cell activation pathway. SPG21 Protein, Mouse (sf9, His) is the recombinant mouse-derived SPG21 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The SPG21 protein acts as a negative regulator in CD4-dependent T cell activation, suggesting a potential role in the regulation of immune responses. By interacting directly with CD4, it affects key components of the T cell activation pathway. SPG21 Protein, Mouse (sf9, His) is the recombinant mouse-derived SPG21 protein, expressed by Sf9 insect cells , with N-His labeled tag.
Background
The SPG21 protein appears to function as a negative regulatory factor in CD4-dependent T-cell activation, suggesting a potential role in modulating immune responses. This regulatory function involves direct interactions with CD4, emphasizing its influence on key components of the T-cell activation pathway. Additionally, SPG21 protein interacts with ALDH16A1, indicating its involvement in diverse molecular interactions that may extend beyond T-cell regulation. Further exploration into the specific mechanisms and downstream effects of SPG21 in the context of CD4-dependent T-cell activation could provide valuable insights into its role in immune modulation and cellular processes beyond the immune system.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag N-6*His
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Accession
Q9CQC8-1 (M1-P308)
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Molecular Construction
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N-term
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6*His
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SPG21 (M1-P308)
Accession # Q9CQC8-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
SPG21; MAST; SPG21 Abhydrolase Domain Containing, Maspardin; Spastic Paraplegia 21 (Autosomal Recessive, Mast Syndrome); ACP33; Acid Cluster Protein 33; Maspardin; SPG21, Maspardin; BM-019; Spastic Paraplegia 21 Autosomal Recessive Mast Syndrome Protein;
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AA Sequence
MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSVVSAEELEVQKGRLGLSQEEP
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Predicted Molecular Mass
35 kDa
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Molecular Weight
Approximately 52 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, pH 8.0, 50% glycerol.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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