Testican 3/SPOCK3 Protein, Mouse (HEK293, His)
The Testican 3/SPOCK3 protein may be involved in different steps of neurogenesis, suggesting a multifaceted role in neuronal cell development. It inhibits pro-matrix metalloproteinase 2 (MMP-2) processing through MT1-MMP and MT3-MMP and regulates MMP-2 activity. Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Testican 3/SPOCK3 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The Testican 3/SPOCK3 protein may be involved in different steps of neurogenesis, suggesting a multifaceted role in neuronal cell development. It inhibits pro-matrix metalloproteinase 2 (MMP-2) processing through MT1-MMP and MT3-MMP and regulates MMP-2 activity. Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Testican 3/SPOCK3 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
Testican 3/SPOCK3 protein is implicated in potentially participating in diverse steps of neurogenesis, suggesting its multifaceted role in the intricate processes of neural cell development. Additionally, it inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP, indicating a regulatory function in the modulation of MMP-2 activity. Furthermore, Testican 3/SPOCK3 may interfere with tumor invasion, as suggested by similarity with other proteins. The comprehensive functions attributed to Testican 3/SPOCK3 underscore its significance in both neurodevelopmental processes and potential involvement in the regulation of extracellular matrix dynamics related to tumor invasion.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q8BKV0-1 (A23-I436)
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Molecular Construction
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N-term
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SPOCK3 (A23-I436)
Accession # Q8BKV0-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
SPOCK3; CDNA FLJ59873, Highly Similar To Testican-3; SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 3; Uncharacterized Protein Tmp_locus_3; Testican-3; Alternative Protein SPOCK3; Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan
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AA Sequence
AAAVAVAGGRSDGGNFLDEKQWLTTISQYDKEVGQWNKFRDEVEDDYFRTWNPGKPFDQALDPAKDPCLKTKCSRHKVCITQDAQTALCISHRRLTHSMKEVGGSHKQWRGLPSSTCKPCPIAYASPVCGSDGHSYSSQCKLEYQACVLGKQISIKCEGRCPCPSDKSMNIGRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKALLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCHTELSNIQKRQGIKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADCAIDFEISGDFASGDFREWTDDEGEEDDIMNDKDDIEDDDEDEGDDDDDGDVHDGYI
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Predicted Molecular Mass
47.9 kDa
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Molecular Weight
Approximately 58-60 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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