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  4. Testican 3/SPOCK3 Protein, Mouse (HEK293, His)

Testican 3/SPOCK3 Protein, Mouse (HEK293, His)

Cat. No.: HY-P71352
Handling Instructions

Testican 3/SPOCK3 Protein potentially participates in diverse neurogenesis steps, indicating a multifaceted role in neural cell development. It inhibits pro-matrix metalloproteinase 2 (MMP-2) processing by MT1-MMP and MT3-MMP, regulating MMP-2 activity. Testican 3/SPOCK3's similarity to other proteins suggests interference with tumor invasion. Its comprehensive functions underscore significance in neurodevelopment and potential involvement in regulating extracellular matrix dynamics related to tumor invasion. Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Testican 3/SPOCK3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is 414 a.a., with molecular weight of 58-60 kDa.

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Description

Testican 3/SPOCK3 Protein potentially participates in diverse neurogenesis steps, indicating a multifaceted role in neural cell development. It inhibits pro-matrix metalloproteinase 2 (MMP-2) processing by MT1-MMP and MT3-MMP, regulating MMP-2 activity. Testican 3/SPOCK3's similarity to other proteins suggests interference with tumor invasion. Its comprehensive functions underscore significance in neurodevelopment and potential involvement in regulating extracellular matrix dynamics related to tumor invasion. Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Testican 3/SPOCK3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is 414 a.a., with molecular weight of 58-60 kDa.
Background

Testican 3/SPOCK3 protein is implicated in potentially participating in diverse steps of neurogenesis, suggesting its multifaceted role in the intricate processes of neural cell development. Additionally, it inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP, indicating a regulatory function in the modulation of MMP-2 activity. Furthermore, Testican 3/SPOCK3 may interfere with tumor invasion, as suggested by similarity with other proteins. The comprehensive functions attributed to Testican 3/SPOCK3 underscore its significance in both neurodevelopmental processes and potential involvement in the regulation of extracellular matrix dynamics related to tumor invasion.
Species

Mouse
Source

HEK293
Tag

C-6*His
Accession

Q8BKV0-1 (A23-I436)
Gene ID

72902  [NCBI]
Molecular Construction
N-term
SPOCK3 (A23-I436)
Accession # Q8BKV0-1
6*His
C-term
Synonyms
Testican-3; Spock3
AA Sequence

AAAVAVAGGRSDGGNFLDEKQWLTTISQYDKEVGQWNKFRDEVEDDYFRTWNPGKPFDQALDPAKDPCLKTKCSRHKVCITQDAQTALCISHRRLTHSMKEVGGSHKQWRGLPSSTCKPCPIAYASPVCGSDGHSYSSQCKLEYQACVLGKQISIKCEGRCPCPSDKSMNIGRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKALLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCHTELSNIQKRQGIKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADCAIDFEISGDFASGDFREWTDDEGEEDDIMNDKDDIEDDDEDEGDDDDDGDVHDGYI

Molecular Weight

58-60 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Testican 3/SPOCK3 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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