TLR3 Protein, Cynomolgus (681a.a, HEK293, His)
The TLR3 protein is part of the Toll-like receptor family and is critical in innate immunity, particularly the detection of viral double-stranded RNA. Its recognition initiates signaling cascades leading to the production of pro-inflammatory cytokines and activation of immune cells. TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is the recombinant cynomolgus-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The TLR3 protein is part of the Toll-like receptor family and is critical in innate immunity, particularly the detection of viral double-stranded RNA. Its recognition initiates signaling cascades leading to the production of pro-inflammatory cytokines and activation of immune cells. TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is the recombinant cynomolgus-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag.
Background
The TLR3 protein belongs to the Toll-like receptor family, a group of proteins involved in innate immune responses. TLR3 plays a crucial role in detecting viral double-stranded RNA, which is a common feature of many viruses. Upon recognition, TLR3 triggers a signaling cascade that leads to the production of pro-inflammatory cytokines and the activation of immune cells. This protein is primarily expressed in immune cells, such as dendritic cells and macrophages, but can also be found in other cell types. Activation of TLR3 is essential for antiviral defense and immune surveillance against viral infections. However, dysregulation of TLR3 signaling has been associated with various autoimmune and inflammatory diseases. Further research is needed to uncover the full extent of TLR3's role in immune responses and its potential as a therapeutic target.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
A0A2K5WT39 (S31-E711)
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Gene ID102138517
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Molecular Construction
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N-term
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TLR3 (S31-E711)
Accession # A0A2K5WT39 -
8*His
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C-term
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Protein Length
Partial
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Synonyms
TLR3; CD283 Antigen; Toll Like Receptor 3; TLR3 Protein; Toll-Like Receptor 3; IIAE2; CD283; IMD83; Toll-Like Receptor 3, Isoform CRA_b
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AA Sequence
SSTNKCTVSQEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTILDVGFNSISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELGILANSSLKKLELSSNQIKEFSPGCFHAIGRLLGLFLNNVQLGPRLTEKLCLQLANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSHNNLNVIGNDSFVWLPHLEYFFLEYNNIQHLLSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFRWLTCLEHLNMEDNDISGIKSNMFTGLINLKYLSLSNSFTSLQTLTNETFVSLAHSPLHILNLTKNKISKIESGAFSWLGHLEVLDLGLNEIGQELTGQEWSGLENIFEIYLSYNKYLQLTKNSFALVRSLQRLMLRRVALKNVDCSPSPFQPLGNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPVYFLKGLSHLHILNLESNGFDEIPVEVFKDLSELKIIDLGLNNLNTLPASVFDNQVSLKSLNLQKNLITSVEKKVFGPAFRNLSNLDMRFNPFDCTCESIAWFVNWINKTHANIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFE
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Predicted Molecular Mass
78 kDa
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Molecular Weight
Approximately 95-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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