TLR3 Protein, Cynomolgus (681a.a, HEK293, His)

TLR3 Protein, part of the Toll-like receptor family, is vital in innate immunity, specifically detecting viral double-stranded RNA. Its recognition initiates a signaling cascade, leading to pro-inflammatory cytokine production and immune cell activation. Predominantly expressed in immune cells like dendritic cells, TLR3's activation is crucial for antiviral defense. Dysregulated TLR3 signaling links to autoimmune and inflammatory diseases, highlighting its potential therapeutic relevance, warranting further research to fully comprehend its immune response role. TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is the recombinant cynomolgus-derived TLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is 681 a.a., with molecular weight of 95-115 kDa.

The TLR3 protein belongs to the Toll-like receptor family, a group of proteins involved in innate immune responses. TLR3 plays a crucial role in detecting viral double-stranded RNA, which is a common feature of many viruses. Upon recognition, TLR3 triggers a signaling cascade that leads to the production of pro-inflammatory cytokines and the activation of immune cells. This protein is primarily expressed in immune cells, such as dendritic cells and macrophages, but can also be found in other cell types. Activation of TLR3 is essential for antiviral defense and immune surveillance against viral infections. However, dysregulation of TLR3 signaling has been associated with various autoimmune and inflammatory diseases. Further research is needed to uncover the full extent of TLR3's role in immune responses and its potential as a therapeutic target.

Cynomolgus

HEK293

C-His

A0A2K5WT39 (S31-E711)

102138517

95-115 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.