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  6. TNFRSF13B Protein, Human (HEK293, His)

TNFRSF13B Protein, Human (HEK293, His)

Cat. No.: HY-P74506
Handling Instructions

TNFRSF13B protein is a receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS and exhibits high-affinity binding to both ligands. Its activation stimulates B-cell and T-cell function and modulates humoral immunity through calcineurin-dependent NF-AT activation as well as NF-kappa-B and AP-1 activation. TNFRSF13B Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF13B protein, expressed by HEK293 , with C-His labeled tag. The total length of TNFRSF13B Protein, Human (HEK293, His) is 119 a.a., with molecular weight of 18-24 kDa.

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Description

TNFRSF13B protein is a receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS and exhibits high-affinity binding to both ligands. Its activation stimulates B-cell and T-cell function and modulates humoral immunity through calcineurin-dependent NF-AT activation as well as NF-kappa-B and AP-1 activation. TNFRSF13B Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF13B protein, expressed by HEK293 , with C-His labeled tag. The total length of TNFRSF13B Protein, Human (HEK293, His) is 119 a.a., with molecular weight of 18-24 kDa.

Background

TNFRSF13B Protein serves as the receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS, demonstrating high-affinity binding to both ligands. Its activation results in calcineurin-dependent activation of NF-AT, along with the activation of NF-kappa-B and AP-1, thereby playing a crucial role in stimulating B- and T-cell function and regulating humoral immunity. Additionally, TNFRSF13B binds TRAF2, TRAF5, and TRAF6, suggesting its involvement in various signaling pathways. Notably, it interacts with the NH2-terminal domain of CAMLG using its C-terminus.

Species

Human

Source

HEK293

Tag

C-His

Accession

O14836-2 (S2-T120)

Gene ID
Molecular Construction
N-term
TNFRSF13B (S2-T120)
Accession # O14836-2
His
C-term
Synonyms
Tumor necrosis factor receptor superfamily member 13B; TACI; CD267; Tnfrsf13b
Molecular Weight

18-24 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

TNFRSF13B Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TNFRSF13B Protein, Human (HEK293, His)
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HY-P74506
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