TROP-2 Protein, Canine (HEK293, His)
The TROP-2 protein emerged as a potential growth factor receptor, implying involvement in cellular processes related to growth and signaling. As a putative receptor, TROP-2 may play a crucial role in transducing signals that regulate cell growth and proliferation. TROP-2 Protein, Canine (HEK293, His) is the recombinant canine-derived TROP-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TROP-2 Protein, Canine (HEK293, His) is 243 a.a., with molecular weight of 40-50 kDa.
- Species: Canine
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The TROP-2 protein emerged as a potential growth factor receptor, implying involvement in cellular processes related to growth and signaling. As a putative receptor, TROP-2 may play a crucial role in transducing signals that regulate cell growth and proliferation. TROP-2 Protein, Canine (HEK293, His) is the recombinant canine-derived TROP-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TROP-2 Protein, Canine (HEK293, His) is 243 a.a., with molecular weight of 40-50 kDa.
Background
The TROP-2 protein emerges as a potential growth factor receptor, suggesting its involvement in cellular processes related to growth and signaling. As a putative receptor, TROP-2 may play a crucial role in transducing signals that regulate cell growth, proliferation, and potentially other cellular functions. The specific ligands and downstream pathways associated with TROP-2-mediated growth factor signaling remain areas for further investigation. Unraveling the detailed molecular mechanisms and functional implications of TROP-2 in growth factor signaling will contribute to a comprehensive understanding of its role in cellular physiology and may open avenues for therapeutic interventions targeting this receptor.
Technical Parameters
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Species Canine
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Source HEK293
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Tag C-His
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Accession
XP_852842.5 (Q39-T281)
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Molecular Construction
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N-term
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TROP-2 (Q39-T281)
Accession # XP_852842.5 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
TACSTD2; Epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic Carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2;
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AA Sequence
QGNCTCATNKMTLCRADGPGGRCRCHLPGSDAPLDCSTLTSKCLLLKARARAKSGRALVRPGEHALLDNDGLYDPDCDRDGRFKARQCNQTSVCWCVNSVGVRRTDKGDRSLRCDELVRTHHILLDLRHRPAARAFNRSELDAELRRLFRERYLLRPRFVAAVHYERPTIQIELRQNASDKAPGDVDIADAAYYFERDVKGESLFPGRGGLDLRVRGEPLQVERTLIYYLDEKPPQFSMKRLT
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Predicted Molecular Mass
29.4 kDa
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Molecular Weight
Approximately 40-50 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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