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TRPC6 Protein, Human (HEK293, Flag, His, Strep)

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TRPC6 Protein, Human (HEK293, Flag, His, Strep) is the recombinant human-derived TRPC6, expressed by HEK293 , with Strep, His, Flag labeled tag. ,

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • TRPC6 Protein, Human (HEK293, Flag, His, Strep) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

TRPC6 Protein, Human (HEK293, Flag, His, Strep) is the recombinant human-derived TRPC6, expressed by HEK293 , with Strep, His, Flag labeled tag. ,

Background

TRPC6 forms a receptor-activated non-selective calcium-permeant cation channel (by similar: PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). It is likely operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. The channel can be activated by diacylglycerol (DAG) in a membrane-delimited manner, independent of protein kinase C (by similar: PubMed:26892346). Current evidence suggests that TRPC6 does not appear to be activated by intracellular calcium store depletion.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag N-6*His;N-Flag;C-Strep
  • Accession

    Q9Y210-1 (M1-R931)

  • Gene ID
    7225
  • Protein Length

    Full Length of Isoform-1

  • Synonyms

    TRPC6; TRP6; Short transient receptor potential channel 6; TrpC6; Transient receptor protein 6; TRP-6; TrpC6; Transient Receptor Potential Cation Channel, Subfamily C, Member 6; FSGS2; Transient Receptor Potential Cation Channel Subfamily C Member 6; Foca

  • AA Sequence

    MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR

  • Purity

    ≥ 80%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution.

Formulation

Supplied as a 0.22 μm filtered solution of 20 mM HEPES pH 8.0, 150 mM NaCl, 0.05% GDN (w/v), 0.01 mg/ml soybean lipids, 1 mM TCEP, 1 mM EDTA.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Please use rapid thawing with running water to thaw the protein.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Desired Reconstitution Concentration Desired Reconstitution Concentration
Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • TRPC6 Protein, Human (HEK293, Flag, His, Strep) Product Image
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  • TRPC6 Protein, Human (HEK293, Flag, His, Strep) Product Image