VSD4-NaV1.7-NaVPas Protein, Human (HEK293, Flag, Strep)
Based on 1 Customer Validation
VSD4-NaV1.7-NaVPas Protein, Human (HEK293, Flag, Strep) is the recombinant human-derived VSD4-NaV1.7-NaVPas, expressed by HEK293 , with Strep, Flag labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
VSD4-NaV1.7-NaVPas Protein, Human (HEK293, Flag, Strep) is the recombinant human-derived VSD4-NaV1.7-NaVPas, expressed by HEK293 , with Strep, Flag labeled tag.
Background
VSD4-NaV1.7-NaVPas is the pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Nav channels, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation, they allow Na(+) ions to selectively pass through the pore along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. by similar: Nav1.7 is functionally linked to pain perception.
Technical Parameters
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Species Human
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Source HEK293
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Tag Strep;Flag
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Accession
Q15858-1 (S257-H273&G1501-I1630)&D0E0C2 (M1-L269&K287-P1155&R1286-G1505)
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Gene ID6335
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Synonyms
SCN9A; Neuroendocrine Sodium Channel; Sodium Voltage-Gated Channel Alpha Subunit 9; Peripheral Sodium Channel 1; NENA; HNE-Na; PN1; Sodium Channel, Voltage Gated, Type IX Alpha Subunit; Nav1.7; Voltage-Gated Sodium Channel Alpha Subunit Nav1.7; NE-NA; Vol
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Predicted Molecular Mass
178.8 kDa
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Molecular Weight
Approximately 180 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM HEPES, pH 7.5, 100 mM NaCl, 0.01% (w/v) GDN, 0.002% (w/v) CHS.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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