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Cat. No.: HY-N8400

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Roridin L2

Name: Roridin L2
Brand: MedChemExpress
SKU: HY-N8400
Price: 370.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Roridin L2 is an inhibitor of the peptidyl transferase center of the 60S ribosomal subunit. Roridin L2 irreversibly binds to this center and inhibits protein biosynthesis.

For research use only. We do not sell to patients.

Purity : 99.90%
CAS No.: 85124-22-7
Formula: C₂₉H₃₈O₉
Molecular Weight:530.61

Storage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Roridin L2 Chemical Structure

CAS No.: 85124-22-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Roridin L2 is an inhibitor of the peptidyl transferase center of the 60S ribosomal subunit. Roridin L2 irreversibly binds to this center and inhibits protein biosynthesis^[1]^[2].

In Vitro

Roridin L2 (0-50 μM; 24 h) decreases viability of NuLi-1 cells and THP-1 macrophages with an IC₅₀ in the lower μM range^[2].
Roridin L2 (up to 1000 ng/mL; 48 h) is non-cytotoxic and does not induce apoptosis or DNA fragmentation in PC-12 neuronal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[2]

View Protocol

Cell Line:

human bronchial epithelial NuLi-1 cells and THP-1 macrophages
Concentration:

0 to 50 μM
Incubation Time:

24 h
Result:

Showed an IC₅₀ in the lower μM range.

Chemical Information

CAS No. 85124-22-7
Appearance Liquid
Molecular Weight 530.61
Formula C₂₉H₃₈O₉
Color Colorless to light yellow
SMILES

CC1=C[C@@]2([C@](CO)(CC1)[C@@]3([C@]4([C@]([H])(O2)C[C@H]3OC(/C=C\C=C\C(C(C)O)OCCC5=CC(OC5)=O)=O)OC4)C)[H]
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Stachybotrys chartarum
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Islam Z, et al. Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. Journal of Toxicology and Environmental Health, Part A. 2009 Sep 16;72(20):1242-51. [Content Brief]

[2]. Wolff A, et al. Establishment of a Human Cell-Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold. Environmental toxicology. 2026 Jul 22.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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