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Cat. No.: HY-182352

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RXRγ antagonist-1

RXRγ antagonist-1 (HX531 analogue) is an RXRγ antagonist and can be used as a target protein ligand for the synthesis of PROTAC WCF-598 (HY-182331).

For research use only. We do not sell to patients.

Formula: C₂₉H₃₁N₃O₂
Molecular Weight:453.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RXRγ antagonist-1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

RXRγ antagonist-1 (HX531 analogue) is an RXRγ antagonist and can be used as a target protein ligand for the synthesis of PROTAC WCF-598 (HY-182331)^[1].

IC₅₀ & Target^[1]

RXRγ

All RAR/RXR Isoforms :

Chemical Information

Molecular Weight 453.58
Formula C₂₉H₃₁N₃O₂
SMILES

NC1=CC2=C(N(C3=CC4=C(C=C3C(C5=CC=C(C=C5)C(O)=O)=N2)C(C)(C)CCC4(C)C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Discovery of a Potent RXRγ Degrader WCF-598 for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. Published online March 20, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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RXRγ antagonist-1

All RAR/RXR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RXRγ antagonist-1 Related Classifications

HY-182352 Related Classifications