2. PROTAC
  3. Molecular Glues
  4. (S)-ACE-OH

(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98.

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(S)-ACE-OH

(S)-ACE-OH 構造式

容量 価格（税別） 在庫状況 数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 616 在庫あり
Solution
10 mM * 1 mL in DMSO USD 616 在庫あり
Oil
5 mg $560 在庫あり
10 mg $900 在庫あり
25 mg $1550 在庫あり
50 mg $2170 在庫あり
100 mg $2900 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of (S)-ACE-OH:

(S)-ACE-OH 関連抗体

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製品説明

(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].

分子量

328.47

分子式

C19H24N2OS
Appearance

Oil

Color

Off-white to light yellow

SMILES

C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (304.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0444 mL 15.2221 mL 30.4442 mL
5 mM 0.6089 mL 3.0444 mL 6.0888 mL
10 mM 0.3044 mL 1.5222 mL 3.0444 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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濃度 （終了）

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0444 mL 15.2221 mL 30.4442 mL 76.1105 mL
5 mM 0.6089 mL 3.0444 mL 6.0888 mL 15.2221 mL
10 mM 0.3044 mL 1.5222 mL 3.0444 mL 7.6110 mL
15 mM 0.2030 mL 1.0148 mL 2.0296 mL 5.0740 mL
20 mM 0.1522 mL 0.7611 mL 1.5222 mL 3.8055 mL
25 mM 0.1218 mL 0.6089 mL 1.2178 mL 3.0444 mL
30 mM 0.1015 mL 0.5074 mL 1.0148 mL 2.5370 mL
40 mM 0.0761 mL 0.3806 mL 0.7611 mL 1.9028 mL
50 mM 0.0609 mL 0.3044 mL 0.6089 mL 1.5222 mL
60 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL
80 mM 0.0381 mL 0.1903 mL 0.3806 mL 0.9514 mL
100 mM 0.0304 mL 0.1522 mL 0.3044 mL 0.7611 mL
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(S)-ACE-OH Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-ACE-OHMolecular GluesAnticancermolecular glueE3 ubiquitin ligasenuclear porinInhibitorinhibitorinhibit

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製品名:
(S)-ACE-OH
製品番号:
HY-169325
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