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United States

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製品番号: HY-P12339

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S10 peptide

S10 peptide is an amphipathic peptide delivery agent that comprises an endosomolytic domain linked to a cell-penetrating peptide via a glycine-serine linker. S10 peptide serves as a delivery vehicle through amphipathic peptide-mediated membrane interactions. S10 peptide is used in molecular delivery-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₆₁H₂₇₂N₅₈O₄₀
分子量:3660.25

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

S10 peptide 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

S10 peptide (S10) efficiently delivers peptide and PMO conjugates to HeLa cells; the conjugate form with a disulfide-PEG12 linker exhibits the optimal delivery efficiency, and such conjugates also achieve splice switching and induce EGFP expression in HeLa EGFP-654 cells^[1].
S10 peptide (S10) (5-20 μM; 15 min) efficiently delivers GFP-NLS protein to primary ferret airway basal cells and polarized airway epithelium without detectable toxicity^[2].
S10 peptide (20 μM; 15 min) enables genomic editing delivery of Cas RNP in ferret airway basal cells and polarized epithelium; and exhibits undetectable toxicity to polarized ferret airway epithelium^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

Polarized primary ferret airway ALI epithelia
Concentration:

20 μM
Incubation Time:

15 min (RT); 24 h (post-delivery)
Result:

Showed undetectable toxicity to ferret airway epithelia as assessed by the LDH assay.

体内実験

S10 peptide (S10)‑derived conjugate S10‑SS‑PEG₁₂‑nls* (20‑40 µM; intranasal administration; single dose) is the optimal conjugate for delivering nls* to mouse airway epithelial cells^[1].
S10 peptide-derived S10-SS-PMO and S10-SS-PEG₁₂-PMO (40 µM; intranasal administration; single dose) promote splice switching in lung epithelial cells of CAG-EGFP-654 mice^[1].
S10 peptide (intratracheal/intralaryngotracheal; single administration) efficiently delivers proteins, peptides, and Cas9 RNPs to ferret airway epithelium in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 3660.25
分子式 C₁₆₁H₂₇₂N₅₈O₄₀
SMILES

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(NCC(N[C@@H](CO)C(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
配列

Lys-Trp-Lys-Leu-Ala-Arg-Ala-Phe-Ala-Arg-Ala-Ile-Lys-Lys-Leu-Gly-Gly-Ser-Gly-Gly-Gly-Ser-Tyr-Ala-Arg-Ala-Leu-Arg-Arg-Gln-Ala-Arg-Thr-Gly
シーケンスの短縮

KWKLARAFARAIKKLGGSGGGSYARALRRQARTG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Auger M, et al. Enhancing peptide and PMO delivery to mouse airway epithelia by chemical conjugation with the amphiphilic peptide S10. Molecular therapy. Nucleic acids. 2024 Sep 10;35(3):102290.

[2]. Luo M, et al. Genome Editing in Ferret Airway Epithelia Mediated by CRISPR/Nucleases Delivered with Amphiphilic Shuttle Peptides. Human gene therapy. 2023 Aug;34(15-16):705-718.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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