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Cat. No.: HY-188127

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SARS-CoV-2-IN-125

SARS-CoV-2-IN-125 is a SARS-CoV-2 main protease (M_pro) inhibitor with an IC₅₀ of 0.15 μM. SARS-CoV-2-IN-125 inhibits SARS-CoV-2 M_pro enzymatic activity, a component essential for viral replication. SARS-CoV-2-IN-125 can be used for the research of covid-19.

For research use only. We do not sell to patients.

CAS No.: 60230-38-8
Formula: C₁₂H₁₆N₂O₄S₄
Molecular Weight:380.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SARS-CoV-2-IN-125 Chemical Structure

CAS No.: 60230-38-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

SARS-CoV-2-IN-125 (compound 2a) potently inhibits purified recombinant SARS-CoV-2 M_pro with an IC₅₀ of 0.15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 60230-38-8
Molecular Weight 380.53
Formula C₁₂H₁₆N₂O₄S₄
SMILES

S=C(N1[C@@H](CCC1)C(O)=O)SSC(N2[C@@H](CCC2)C(O)=O)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu YS, et al. Discovery of a Highly Promising Disulfide Derivative Scaffold as Inhibitor of SARS-CoV-2 Main Protease. Chem Biodivers. 2024 Nov;21(11):e202401034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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