2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-36

SARS-CoV-2-IN-36 is a potent SARS-CoV-2 Mpro (SARS-CoV) inhibitor with an IC50 of 2.37 μM and a Kd of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells.

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SARS-CoV-2-IN-36 Chemical Structure

SARS-CoV-2-IN-36 Chemical Structure

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SARS-CoV-2-IN-36 Related Antibodies

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Description

SARS-CoV-2-IN-36 is a potent SARS-CoV-2 Mpro (SARS-CoV) inhibitor with an IC50 of 2.37 μM and a Kd of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells[1].

In Vitro

SARS-CoV-2-IN-36 (compound 58) inhibit the replication of the Wuhan (UC-1074),South African (RG2674), and UK (NVDBB-2220) SARS-CoV-2 variants, with IC50 values of 5.0 μM, 39.9 μM, and 5.2 μM, respectively. SARS-CoV-2-IN-36 alters cell morphology only at concentrations above ≥100 μM and does not inhibit Vero cell growth up to a concentration >100 μM[1].
SARS-CoV-2-IN-36 (compound 58) lacks antiviral activity against two herpesviruses (varicella-zoster virus and human cytomegalovirus) in human embryonic lung fibroblasts. SARS-CoV-2-IN-36 shows a very low cytotoxicity also against embryonic lung fibroblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2-IN-36 Related Antibodies
In Vivo

PK analysis of plasma concentrations, with ± SD, after intranasal (IN) and oral (PO) administration in male C57BL6 mice[1].

Route Dose (mg/kg) Concentration (mg/mL) Number of animals Cmax (ng/mL) Tmax (h) AUCt/dose (h*kg*ng/mL/mg)
IN 0.5 1.0 3 177.97±26.15 0.25±0.00 188.05±32.52
IN 1.25 2.5 3 325.95±42.45 0.25±0.00 150.62±23.80
PO 10 10 3 22.72±4.42 0.75±0.43 3.07±0.92
PO 25 2.5 3 33.67±3.42 0.5±0.43 2.00±0.51

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

343.38

Formula

C17H21N5O3
SMILES

[H]C(C(N[C@H](C(N[C@@H](CC1=CNC=N1)C=O)=O)CC2=CC=CC=C2)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2-IN-36 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-36SARS-CoVSARS coronavirusSARS-CoV-2 MproUC-1074RG2674NVDBB-2220 variantsintranasal administrationInhibitorinhibitorinhibit

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