SARS-CoV-2-IN-36
SARS-CoV-2-IN-36 is a potent SARS-CoV-2 Mpro (SARS-CoV) inhibitor with an IC50 of 2.37 μM and a Kd of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells.
For research use only. We do not sell to patients.
- Formula: C17H21N5O3
- Molecular Weight:343.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SARS-CoV-2-IN-36 (compound 58) inhibit the replication of the Wuhan (UC-1074),South African (RG2674), and UK (NVDBB-2220) SARS-CoV-2 variants, with IC50 values of 5.0 μM, 39.9 μM, and 5.2 μM, respectively. SARS-CoV-2-IN-36 alters cell morphology only at concentrations above ≥100 μM and does not inhibit Vero cell growth up to a concentration >100 μM[1].
SARS-CoV-2-IN-36 (compound 58) lacks antiviral activity against two herpesviruses (varicella-zoster virus and human cytomegalovirus) in human embryonic lung fibroblasts. SARS-CoV-2-IN-36 shows a very low cytotoxicity also against embryonic lung fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Route | Dose (mg/kg) | Concentration (mg/mL) | Number of animals | Cmax (ng/mL) | Tmax (h) | AUCt/dose (h*kg*ng/mL/mg) |
| IN | 0.5 | 1.0 | 3 | 177.97±26.15 | 0.25±0.00 | 188.05±32.52 |
| IN | 1.25 | 2.5 | 3 | 325.95±42.45 | 0.25±0.00 | 150.62±23.80 |
| PO | 10 | 10 | 3 | 22.72±4.42 | 0.75±0.43 | 3.07±0.92 |
| PO | 25 | 2.5 | 3 | 33.67±3.42 | 0.5±0.43 | 2.00±0.51 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 343.38
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Formula C17H21N5O3
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SMILES
[H]C(C(N[C@H](C(N[C@@H](CC1=CNC=N1)C=O)=O)CC2=CC=CC=C2)=O)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2-IN-36 Related Classifications
HY-151988 Related Classifications
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