SDH-IN-47

SDH-IN-47 (compound G33) exerts potent inhibitory effects on the mycelial growth of Valsa mali, Sclerotinia sclerotiorum, Botrytis cinerea, Curvularia lunata, and Phytophthora capsici, with EC₅₀ values of 1.43, 1.50, 0.17, 1.95, and 0.42 mg/L, respectively^[1].
SDH-IN-47 (1.0 mg/L) disrupts the surface morphology and intracellular ultrastructure of Botrytis cinerea hyphae, inducing plasmolysis and cytoplasmic disorder^[1].
SDH-IN-47 (0.3 mg/L) disrupts the membrane integrity of Botrytis cinerea hyphae, allowing PI to penetrate into the cells, and also dissipates the mitochondrial membrane potential of Botrytis cinerea hyphae^[1].
SDH-IN-47 potently inhibits purified succinate dehydrogenase from Botrytis cinerea with an IC₅₀ of 1.80 μM^[1].
SDH-IN-47 (0.6-10 mg/L; 5 min) potently inhibits succinate dehydrogenase in Botrytis cinerea, with an IC₅₀ value of 1.80 μM^[1].
SDH-IN-47 binds tightly to the SDH active site of Botrytis cinerea, with a CDOCKER interaction energy of -44.03 kcal/mol, and forms multiple hydrogen bonds and hydrophobic interactions with key residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.