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Cat. No.: HY-106847

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SDZ-MRL 953

SDZ-MRL 953 is a novel immunostimulatory lipid analogue. SDZ-MRL 953 has no pulmonary toxicity and good safety. SDZ-MRL 953 can be used for research on acute lung injury.

For research use only. We do not sell to patients.

CAS No.: 123136-61-8
Formula: C₄₈H₉₂NO₁₄P
Molecular Weight:938.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SDZ-MRL 953 Chemical Structure

CAS No.: 123136-61-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SDZ-MRL 953 is a novel immunostimulatory lipid analogue. SDZ-MRL 953 has no pulmonary toxicity and good safety. SDZ-MRL 953 can be used for research on acute lung injury^[1].

Chemical Information

CAS No. 123136-61-8
Molecular Weight 938.22
Formula C₄₈H₉₂NO₁₄P
SMILES

CCCCCCCCCCC[C@@H](O)CC(O[C@@H]1[C@H]([C@H](O[C@H](CO)[C@H]1OC(C[C@H](O)CCCCCCCCCCC)=O)OP(O)(O)=O)NC(C[C@H](O)CCCCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Inhalation Toxicity Study
Inhalation toxicity studies expose rodents to a controlled aerosol, vapor, gas, or smoke atmosphere and assess respiratory and systemic toxicity using exposure-atmosphere characterization, clinical observations, body and organ weights, bronchoalveolar lavage fluid, histopathology, blood chemistry, hematology, and, when included, molecular endpoints such as transcriptomics, proteomics, lipidomics, or tissue burden analysis. The primary biological readouts are airway irritation, pulmonary inflammation, cytotoxicity, altered surfactant or lipid homeostasis, impaired particle clearance, and tissue remodeling, reflected by BALF cell differentials, BALF protein, LDH, phosphatase activities, cytokines, lung weight, microscopic respiratory-tract lesions, and retained lung burden.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nakamura H, et al. Effects of pretreatment with SDZ MRL 953, a novel immunostimulatory lipid A analog, on endotoxin-induced acute lung injury in guinea pigs. Clin Diagn Lab Immunol. 1995 Nov;2(6):672-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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