MCTS1 - MCTS1 re-initiation and release factor Gene

Also Known as MCT1; MCT-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28985

About MCTS1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,604,101-120,621,159 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 206 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues.

Summary

Predicted to enable translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Located in cytosol and plasma membrane. Colocalizes with cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

MCTS1 Products (2)

mRNA Protein Name
NM_001137554.2 NP_001131026.1 malignant T-cell-amplified sequence 1 isoform 2
NM_014060.3 NP_054779.1 malignant T-cell-amplified sequence 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA cap binding IDA
IDA: Inferred from direct assay
16982740 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
enables ribosomal small subunit binding IDA
IDA: Inferred from direct assay
20713520 GOA
enables translation factor activity, non-nucleic acid binding IDA
IDA: Inferred from direct assay
20713520 GOA
Biological Process GO Annotation Evidence References Source
involved in IRES-dependent viral translational initiation IDA
IDA: Inferred from direct assay
20713520 GOA
involved in formation of translation preinitiation complex IDA
IDA: Inferred from direct assay
20713520 GOA
involved in ribosome disassembly IDA
IDA: Inferred from direct assay
20713520 GOA
involved in ribosome disassembly IMP
IMP: Inferred from mutant phenotype
37875108 GOA
involved in translation reinitiation IMP
IMP: Inferred from mutant phenotype
37875108 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
16982740 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCTS1 Protein Structure

PUA

PUA: PUA domain (94 - 170)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

malignant T-cell-amplified sequence 1

  • malignant T-cell amplified sequence 1

MCTS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MCTS1 Q9ULC4 DENR Homo sapiens O43583
Anti Tag CoIP
33961781
Intra
MCTS1 Q9ULC4 DENR Homo sapiens O43583
Y2H Prey Pooling
32296183
Intra
MCTS1 Q9ULC4 DENR Homo sapiens O43583
Y2H Array
32296183
Intra
MCTS1 Q9ULC4 DENR Homo sapiens O43583
Y2H Pooling
16169070
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1804 Tricaprilin 98.0% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12750 AZD3965 Inhibitor 99.96% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13248 AR-C155858 Inhibitor 99.62% Unkown
HY-139665 VB124 Inhibitor 99.86% Unkown
HY-N4115 Syrosingopine Inhibitor 99.52% Unkown
HY-D0067 7ACC1 Inhibitor 99.94% Unkown
HY-122312 BAY-8002 Inhibitor 98.84% Unkown
HY-150314 MCT-IN-1 Inhibitor 99.74% Unkown
HY-138559 GW604714X Inhibitor 98.49% Unkown
HY-18974 MCT1-IN-2 Inhibitor 99.88% Unkown
HY-Y1080 N-Acetyl-R-leucine Inhibitor 99.89% Unkown
HY-75625 2-Hydroxy-4-methoxybenzoic acid 99.64% Unkown
HY-B1804S2 Tricaprilin-d15 98.0% Unkown
HY-119996A AR-C141990 hydrochloride Inhibitor 98.2% Unkown
HY-148574 MCT1-IN-3 Inhibitor 98.65% Unkown
HY-B1804S Tricaprilin-13C3 98.0% Unkown
HY-RS08251 MCTS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119996 AR-C141990 Inhibitor / Unkown
HY-184926 PEG9MA10-PAB10-GalMA10 / Unkown
HY-B1804S1 Tricaprilin-d50 / Unkown
HY-114602 AR-C117977 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992265 Anti-MCT1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MCTS1 VGNC VGNC:54172
Rattus norvegicus MCTS1 RGD RGD:1566390
Mus musculus MCTS1 MGD MGI:1916245
Macaca mulatta MCTS1 VGNC VGNC:74558
Bos taurus MCTS1 VGNC VGNC:56930
Others MCTS1 NCBI