HSF4 - heat shock transcription factor 4 Gene

Also Known as CTM; CTRCT5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3299

About HSF4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,163,761-67,169,941 (from NCBI)

This gene has 29 transcripts (splice variants), 217 orthologues, 9 paralogues and is associated with 5 phenotypes. Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues.

Summary

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or Other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

HSF4 Products (4)

mRNA	Protein	Name
NM_001040667.3	NP_001035757.1	heat shock factor protein 4 isoform b
NM_001374674.1	NP_001361603.1	heat shock factor protein 4 isoform a
NM_001374675.1	NP_001361604.1	heat shock factor protein 4 isoform b
NM_001538.4	NP_001529.2	heat shock factor protein 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8972228	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8972228	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16581800	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8972228	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	8972228	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSF4 Protein Structure

HSF_DNA-bind

0
100
200
300
400
492 a.a.

Protein Preferred Names	Protein Names
heat shock factor protein 4	HSF 4

Related Diseases

Diseases	Alias
Cataract 5, Multiple Types	CTRCT5 Cataract, Marner Type Cataract 5 Multiple Types Cam Cataract, Lamellar Cataract Marner Type Ctm Cataract, Type 5, Multiple Types
Early-Onset Lamellar Cataract
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Anterior Spinal Artery Syndrome	Anterior Spinal Artery Occlusion Syndrome
Posterior Polar Cataract	Cataract, Posterior Polar
Nance-Horan Syndrome	NHS Cataract-Dental Syndrome Cataract, X-Linked, With Hutchinsonian Teeth Mesiodens-Cataract Syndrome Cataract X-Linked With Hutchinsonian Teeth Cataract Dental Syndrome Mesiodens Cataract Syndrome
Senile Cataract
Amblyopia	Lazy Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06411	HSF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20289	Hsf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26797	Hsf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HSF4	VGNC	VGNC:67663
Mus musculus	HSF4	MGD	MGI:1347058
Rattus norvegicus	HSF4	RGD	RGD:1310808
Macaca mulatta	HSF4	VGNC	VGNC:73533
Bos taurus	HSF4	VGNC	VGNC:29984
Others	HSF4	NCBI