VTX-1218
Based on 1 Customer Validation
VTX-1218 is a VSIG4 inhibitor with human Kd 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types.
For research use only. We do not sell to patients.
- Purity: 99.9%
- Molecular Weight:145.32 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
VSIG4
VTX-1218 binds recombinant human, cynomolgus monkey, and rhesus monkey VSIG4 extracellular domain proteins with high affinity, exhibiting Kd values of 7.4 nM, 8.1 nM, and 9.6 nM, respectively[1].
VTX-1218 dose-dependently blocks the interaction of human VSIG4 with its complement ligands C3b and iC3b[1].
VTX-1218 repolarizes tumor-associated macrophages to proinflammatory phenotypes and promotes T cell-mediated tumor killing in primary cell in vitro assays and fresh human tumor cultures[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Q9Y279-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized VSIG4 Protein, Human can bind VTX-1218. The EC50 for this effect is 64.7 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 145.32 kDa
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Color Colorless to light yellow
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SMILES
[3H][V][X1218]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Sazinsky S, et al. Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types. Int J Mol Sci. 2024;25(11):6160. Published 2024 Jun 3. [Content Brief]
[2]. Miyamoto T, et al. Intraperitoneal metastasis of ovarian cancer: new insights on resident macrophages in the peritoneal cavity. Front Immunol. 2023;14:1104694. Published 2023 Apr 25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VTX-1218 Related Classifications
HY-P991181 Related Classifications
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