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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2531 Results for "
Class
" in MedChemExpress (MCE) Product Catalog:
Products (2531)
2531 Results for "Class" in MCE Product Catalog:
製品番号: HY-159899
CAS 番号: 2941327-87-1
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections .
製品番号: HY-165381
CAS 番号: 71555-14-1
研究分野:
ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore with a human mutant p53 R175H binding Ka of 27.4 nM.ZMC2 binds Fe, Cu, Mn, Zn, and other transition metals.ZMC2 facilitates zinc transport across membranes.ZMC2 restores zinc binding to zinc-deficient p53 mutants, restoring wild-type structure and function, including site-specific DNA binding.ZMC2 generates reactive oxygen species (ROS).ZMC2 can be used for the research of cancer .
製品番号: HY-183058
CAS 番号: 2140164-84-5
Target:
研究分野:
EZM8266 is an orally active and selective G9a (EHMT2) histone methyltransferase inhibitor with a human EHMT2 IC50 of 1 pM. EZM8266 reduces repressive H3K9me2 marks at immune-stimulatory gene and endogenous retroviral element promoters. EZM8266 reduces colony formation, migration, and invasion of cancer cells. EZM8266 enhances IFN-γ response, increases MHC class I expression, and enhances CXCL10-mediated T cell recruitment in cancer cells. EZM8266 can be used for the research of hepatocellular carcinoma .
製品番号: HY-B2221B2
CAS 番号: 9004-62-0
研究分野:
Hydroxyethyl cellulose, Viscosity (2%):40000mPa.s is a class of nonionic cellulose ether gel-forming polymers with pH-independent drug release properties. When used as a tablet coating, Hydroxyethyl cellulose, Viscosity (2%):40000mPa.s regulates the water permeation rate, thereby altering the drug release lag time; the higher the viscosity, the longer the drug release lag time. When used as a hydrogel thickener, it increases the dynamic viscosity of the system. Hydroxyethyl cellulose, Viscosity (2%):40000mPa.s can be used in organic synthesis-related research, such as pharmaceutical excipients, hydrogel thickeners, etc.
製品番号: HY-B2221B3
CAS 番号: 9004-62-0
研究分野:
Hydroxyethyl cellulose, Viscosity (2%):6000mPa.s is a class of nonionic cellulose ether gel-forming polymers with pH-independent drug release properties. When used as a tablet coating, Hydroxyethyl cellulose, Viscosity (2%):6000mPa.s regulates the water permeation rate, thereby altering the drug release lag time; the higher the viscosity, the longer the drug release lag time. When used as a hydrogel thickener, it increases the dynamic viscosity of the system. Hydroxyethyl cellulose, Viscosity (2%):6000mPa.s can be used in organic synthesis-related research, such as pharmaceutical excipients, hydrogel thickeners, etc.
製品番号: HY-W009783R
CAS 番号: 73465-43-7
Category:
Target:
製品番号: HY-W015936
CAS 番号: 928-95-0
別名: trans-Hex-2-en-1-ol
Category:
Target:
製品番号: HY-W145545
CAS 番号: 138906-41-9
別名: 4-Methoxyphenyl 3,4,6-Tri-O-acetyl-2-deoxy-2-phthalimido-beta-D-glucopyranoside
製品番号: HY-W585368
CAS 番号: 945921-51-7
研究分野:
BODIPY dyes are a class of small-molecule fluorophores with strong ultraviolet absorption and sharp fluorescence emission peaks. BODIPY dyes can non-specifically label erythrocyte membranes, fail to inhibit the proliferation of Plasmodium falciparum, exhibit weak cytotoxicity against Chinese hamster ovary cells, and have extremely low hemolytic activity. BODIPY dyes serve as a universal scaffold for fluorescent compounds such as laser dyes and fluorescent probes, and can also be used to construct photoelectric and biophotonic molecular assembly units. BODIPY dyes are applicable to research related to live-cell imaging, fluorescent labeling of proteins and DNA, and various biological imaging assays .
製品番号: HY-L928
7,106 compounds
G protein-coupled receptors (GPCRs) are membrane proteins in humans and one of the most important targets in drug discovery. Approximately 35% of launched drugs are targeted GPCRs, making them a crucial class of targets in drug discovery.
The orthosteric site of a GPCR is its endogenous ligand’s (such as neurotransmitters or hormones) binding site. This site plays a central role in signal transduction. Small molecules binding to this site typically contain a protonatable amino group, enabling the formation of salt bridges or hydrogen bonds with acidic residues in the binding pocket. In contrast, the allosteric site does not directly initiate signaling but modulates the signal intensity of the GPCR by altering or stabilizing the conformation of the orthosteric site. Small molecules binding to the allosteric site often contain multiple aromatic rings to occupy hydrophobic pockets and achieve their functional effects.
MCE has collected over 7,106 reported bioactive molecules targeting GPCRs, covering Class A, B, and C GPCRs. These small molecules were subjected to AI representation to extract 2D and 3D features. Subsequently, we do screening by AI score based on similarity to identify molecules in diversity library highly similar to the reported bioactive molecules in both 2D and 3D, with a threshold greater than 0.7. Further screening based on cLogP was applied to select molecules with good lipophilicity, which facilitates the binding of small molecules to GPCRs. This diversity library can be widely applied to the discovery of compounds targeting GPCR proteins.
製品番号: HY-P70656
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: FCGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Mouse
Source:
HEK293
製品番号: HY-P72093
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: ASPN; PLAP1; Asporin; Periodontal Ligament Associated Protein 1; SLRR1C; Periodontal Ligament-Associated Protein 1; PLAP-1; Small Leucine-Rich Protein 1C; Asporin (LRR Class 1); Alternative Protein ASPN; Asporin Proteoglycan; ASPN Protein; FLJ20129; OS3
Species:
Human
Source:
E. coli
製品番号: HY-P72710
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
製品番号: HY-P73522
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: FCGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Human
Source:
HEK293
製品番号: HY-P73832
純度: ≥ 85%, as determined by reducing SDS-PAGE.
別名: MAX; BHLHd5; MYC Associated Transcriptional Regulator X; BHLHd6; MYC Associated Factor X; BHLHd7; BHLHd4; BHLHd8; Protein Max; MAX Protein; Class D Basic Helix-Loop-Helix Protein 4; BHLHD4; Myc-Associated Factor X; PDMCS
Species:
Human
Source:
Sf9 insect cells
製品番号: HY-P76920
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: FCGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Cynomolgus
Source:
HEK293
製品番号: HY-P78262
純度: ≥ 95%, as determined by Bis-Tris PAGE.
別名: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
製品番号: HY-P700514
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: USF1; Upstream Transcription Factor 1; BHLHb11; Major Late Transcription Factor 1; Upstream Stimulatory Factor 1; MLTFI; UEF; Class B Basic Helix-Loop-Helix Protein 11; HYPLIP1; BHLHB11; FCHL1; FCHL; MLTF; USF
Species:
Human
Source:
E. coli
製品番号: HY-P75760A
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: FCGRT; Major Histocompatibility Complex Class I-Like Fc Receptor; Fc Gamma Receptor And Transporter; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 6; Neonatal Fc Receptor; Neonatal Crystallizable Fc Receptor FcRn Splice Variant 5; FcRn; Neonatal
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
