Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
263 Results for "
thiol groups
" in MedChemExpress (MCE) Product Catalog:
Products (263)
263 Results for "thiol groups" in MCE Product Catalog:
Cat. No.: HY-W1049002C
Cat. No.: HY-W1049002D
Cat. No.: HY-W106411
CAS No.: 71865-37-7
Synonyms: Dithio-bis-maleimidoethane
Target:
Research Areas:
DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions .
Cat. No.: HY-172721
CAS No.: 926905-86-4
Cat. No.: HY-D3603
CAS No.: 928817-42-9
Target:
Research Areas:
Benzylguanine-CY5 is a quenched fluorescent dye conjugate based on benzylguanine (BG). Benzylguanine-CY5 possesses the activity of specifically covalently labeling SNAP-tag fusion proteins. Benzylguanine-CY5 exhibits intramolecular fluorescence quenching in the unbound state; upon binding to SNAP-tag, the quenching guanine moiety is cleaved, and its fluorescence intensity increases. Benzylguanine-CY5 can be used for background-free specific fluorescent labeling and imaging studies of SNAP-tag fusion proteins in living cells .
Target:
Research Areas:
Clostripain (Clostridiopeptidase B) is a thiol protease isolated from Clostridium histolyticum. Clostripain exhibits proteolytic activity as well as amidase-esterase activity. The specificity of Clostripain is primarily restricted to arginine residues, but it also shows minor hydrolytic activity toward most lysine-containing substrates. Clostripain catalyzes the ammonolysis of Carbobenzoxyarginyl methyl ester to generate various dipeptides .
Cat. No.: HY-152919
CAS No.: 2387738-43-2
Target:
Research Areas:
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
Cat. No.: HY-D2381
Cat. No.: HY-E70958
Target:
Research Areas:
Carboxypeptidase G, Pseudomonas sp. (EC 3.4.17.11) is a lysosomal thiol-dependent protease that stepwise cleaves γ-glutamylpteroyl polyγ-glutamic acid to generate pteroyl-α-glutamic acid (folic acid) and free glutamic acid. Carboxypeptidase G is highly specific for the γ-glutamyl bond but not for the C-terminal amino acid of the leaving group. Carboxypeptidase G can be activated by Zn 2+ ions.
Cat. No.: HY-P2770B
Target:
Research Areas:
β-Amylase, Barley (EC 3.2.1.2) hydrolyzes the α-(1,4) glucan bonds in polysaccharides composed of three or more α-(1,4)-linked D-glucan units. In the absence of a reducing agent, β-Amylase, Barley (EC 3.2.1.2) rapidly polymerizes via thiol groups.
Cat. No.: HY-D3573
Target:
Research Areas:
AF488 C5 Maleimide is a thiol-reactive Fluorescent dye used to label target proteins and bacterial structures. AF488 C5 Maleimide irreversibly forms covalent thioether conjugates with cysteine thiol groups. AF488 C5 Maleimide stabilizes pre-formed globular low-molecular-weight Tau protein oligomers by blocking cysteine-dependent tau protein aggregation, allowing observation of the internalization process of tau protein oligomers into neuronal cells via confocal microscopy. AF488 C5 Maleimide can label cysteine-modified pili; the outer membrane permeability varies among different bacterial species, allowing imaging via epifluorescence microscopy using a FITC filter set .
Cat. No.: HY-W060216
CAS No.: 59-53-0
Cat. No.: HY-W1048555
Cat. No.: HY-W1048555B
Cat. No.: HY-W1048555C
Cat. No.: HY-W1048555D
Cat. No.: HY-W1048555E
Cat. No.: HY-W1048555H
Cat. No.: HY-D1305
CAS No.: 1443553-08-9
Target:
Research Areas:
ATTO 488 carboxylic acid is a bright green fluorescent dye with high photostability, which is commonly used in protein fluorescent labeling, single-molecule fluorescence imaging and super-resolution microscopy studies. The carboxylic acid form of ATTO 488 can be covalently coupled to primary amines of proteins via activation, or prepared into a maleimide derivative for coupling with thiol groups; it emits green fluorescence after labeling. Ex/Em = 488/524 nm .
Cat. No.: HY-D1390
CAS No.: 2242791-82-6
Synonyms: Sulfo-cyanine5 maleimide potassium
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
