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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2711 Results for "
grape tissue sections
" in MedChemExpress (MCE) Product Catalog:
Products (2711)
2711 Results for "grape tissue sections" in MCE Product Catalog:
Cat. No.: HY-L038
2,574 compounds
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.
MCE Differentiation Inducing Compound Library contains a unique collection of 2,574 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.
Cat. No.: HY-153552
CAS No.: 2758337-19-6
NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose-response, and has been used for tumor diagnosis. NH2-UAMC1110 introduces an active amino group into its structure, enabling it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.), thereby synthesizing molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling processes. Its key activity is high targeting and high affinity, and its core function is to be coupled with bifunctional chelators (such as DOTA, DATA5m) as a targeting module. NH2-UAMC1110 can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
NH2-UAMC1110 TFA is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 TFA is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose effect, and has been used in tumor diagnosis. NH2-UAMC1110 TFA structurally incorporates an active amino group, allowing it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.) to synthesize molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 TFA specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling-related processes. Its key activity is high targeting and high affinity, and its core function is to act as a targeting module coupled with bifunctional chelators (such as DOTA, DATA5m). NH2-UAMC1110 TFA can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
Cat. No.: HY-P991744
Cat. No.: HY-L040
1,172 compounds
Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.
The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.
MCE Anti-diabetic Compound Library owns a unique collection of 1,172 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.
Cat. No.: HY-P7268
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPBP; Macrophage-Derived Growth Factor; Prev. THBGB1; C-X-C Motif Chemokine 7; SCYB7; Beta-Thromboglobulin; CTAP3; NAP-2-L1; CXCL7; Small Inducible Cytokine Subfamily B, Member 7; MDGF; Neutrophil-Activating Peptide-2; LDGF; Low-Affinity Platelet Factor IV; TGB1; Neutrophil-Activating Peptide 2; PBP; Small Inducible Cytokine B7; Platelet Basic Protein; Small-Inducible Cytokine B7; Beta-TG; Thromboglobulin, Beta-1; CTAPIII; CXC Chemokine Ligand 7; LA-PF4; Thrombocidin 1; B-TG1; Thrombocidin 2; NAP-2; CTAP-III; TGB; THBGB; Connective tissue-Activating Peptide III; TC1; Chemokine (C-X-C Motif) Ligand 7; TC2; Pro-Platelet Basic Protein; Leukocyte-Derived Growth Factor
Species:
Human
Source:
E. coli
Cat. No.: HY-D3133
CAS No.: 2410296-16-9
Target:
Research Areas:
HS-CyBz is a Fluorescent probe for H₂S detection, enabling ratiometric optical/photoacoustic dual-modality in/ex vivo imaging. Its detection mechanism relies on nucleophilic substitution of its benzoic ester group by HS⁻, which releases an enolic meso-hydroxyltricarboheptamethine cyanine that then undergoes keto-enol tautomerization to form Cy-ketone; this tautomerization causes distinct shifts in absorption and emission spectra, producing a ratiometric response that reduces interferences from tissue scattering, autofluorescence, and probe concentration. In its initial state, HS-CyBz has an excitation wavelength of 595 nm, with emission bands centered at 805 nm (main) and 630 nm (minor); upon reaction with H₂S, the 805 nm emission band decreases while the 630 nm band drastically increases, and its absorption spectrum shows a sharp band at 775 nm and a shoulder band at 708 nm, which decrease upon H₂S reaction with a minor increase at 850 nm and an isosbestic point at 825 nm. For in vivo optical imaging, excitation at 560 nm is used with emission channels at 620 nm and 790 nm, while in vivo photoacoustic imaging uses excitation at 775 nm and 825 nm. The detection limit of HS-CyBz for H₂S is 0.5 μM, and it shows high selectivity, with only H₂S inducing a distinct enhancement of the emission ratio F₆₃₀/F₈₀₅ and PA ratio PA₈₂₅/PA₇₇₅, while other biochemical species including cations, anions, reactive oxygen species, biothiols, and carboxylesterase trigger only minor changes and do not interfere with H₂S sensing. Tail intravenous injection of HS-CyBz leads to accumulation in the liver of mice, and it can be used to verify endogenous H₂S upregulation triggered by S-adenosyl-L-methionine via ratiometric optical/photoacoustic imaging .
Cat. No.: HY-P706262
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N-Beta-Amyloid Peptide(1-40); ¹⁵N-Aβ(1-40); ¹⁵N-Amyloid β Protein Fragment(1-40); ¹⁵N-Amyloid β-Peptide(1-40)(human); ¹⁵N-β-amyloid(1-40); APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Peptide(1-42); ABPP; Alternative Protein APP; Amyloid Beta (A4) Precursor Protein; Beta-Amyloid Peptide; Amyloid-Beta (A4) Precursor Protein; Amyloid Beta Protein; Alzheimer Disease Amyloid Protein; Alzheimer Disease; Cerebral Vascular Amyloid Peptide; CTFgamma; Amyloid Beta A4 Protein; ABETA; Amyloid-Beta A4 Protein; AAA; Peptidase Nexin-II; PN2; Protease Nexin-II; A4; PN-II; Amyloid Beta Precursor Protein; APPI
Species:
Human
Source:
E. coli
Cat. No.: HY-P706263
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N,¹³C-Beta-Amyloid Peptide(1-40); ¹⁵N,¹³C-Aβ(1-40); ¹⁵N,¹³C-Amyloid β Protein Fragment(1-40); ¹⁵N,¹³C-Amyloid β-Peptide(1-40)(human); ¹⁵N,¹³C-β-amyloid(1-40); APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Peptide(1-42); ABPP; Alternative Protein APP; Amyloid Beta (A4) Precursor Protein; Beta-Amyloid Peptide; Amyloid-Beta (A4) Precursor Protein; Amyloid Beta Protein; Alzheimer Disease Amyloid Protein; Alzheimer Disease; Cerebral Vascular Amyloid Peptide; CTFgamma; Amyloid Beta A4 Protein; ABETA; Amyloid-Beta A4 Protein; AAA; Peptidase Nexin-II; PN2; Protease Nexin-II; A4; PN-II; Amyloid Beta Precursor Protein; APPI
Species:
Human
Source:
E. coli
Cat. No.: HY-P706264
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N-Aβ(1-42); ¹⁵N-Beta-Amyloid(1-42); ¹⁵N-Aβ(1-42); ¹⁵N-Amyloid β Protein Fragment1-42; ¹⁵N-Amyloid β-Peptide(1-42); ¹⁵N-β-Amyloid 42; ¹⁵N-β-Amyloid(1-42); APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Peptide(1-42); ABPP; Alternative Protein APP; Amyloid Beta (A4) Precursor Protein; Beta-Amyloid Peptide; Amyloid-Beta (A4) Precursor Protein; Amyloid Beta Protein; Alzheimer Disease Amyloid Protein; Alzheimer Disease; Cerebral Vascular Amyloid Peptide; CTFgamma; Amyloid Beta A4 Protein; ABETA; Amyloid-Beta A4 Protein; AAA; Peptidase Nexin-II; PN2; Protease Nexin-II; A4; PN-II; Amyloid Beta Precursor Protein; APPI
Species:
Human
Source:
E. coli
Cat. No.: HY-P706265
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N,¹³C-Aβ(1-42); ¹⁵N,¹³C-Beta-Amyloid(1-42); ¹⁵N,¹³C-Aβ(1-42); ¹⁵N,¹³C-Amyloid β Protein Fragment1-42; ¹⁵N,¹³C-Amyloid β-Peptide(1-42); ¹⁵N,¹³C-β-Amyloid 42; ¹⁵N,¹³C-β-Amyloid(1-42); APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Peptide(1-42); ABPP; Alternative Protein APP; Amyloid Beta (A4) Precursor Protein; Beta-Amyloid Peptide; Amyloid-Beta (A4) Precursor Protein; Amyloid Beta Protein; Alzheimer Disease Amyloid Protein; Alzheimer Disease; Cerebral Vascular Amyloid Peptide; CTFgamma; Amyloid Beta A4 Protein; ABETA; Amyloid-Beta A4 Protein; AAA; Peptidase Nexin-II; PN2; Protease Nexin-II; A4; PN-II; Amyloid Beta Precursor Protein; APPI
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
