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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
297 Results for "
DNA-binding
" in MedChemExpress (MCE) Product Catalog:
Products (297)
297 Results for "DNA-binding" in MCE Product Catalog:
Cat. No.: HY-N19791
CAS No.: 13410-15-6
Category:
Monophenols Coumarins Phenols Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Phenylpropanoids Plants Umbelliferae
Target:
Cat. No.: HY-P1758
CAS No.: 153840-64-3
Synonyms: IRRP1
Target:
Research Areas:
Cat. No.: HY-P1758A
Synonyms: IRRP1 acetate
Target:
Research Areas:
Target:
Research Areas:
5-Amino-2'-deoxyuridine is a thymidine analogue and substrate for chemical reaction. 5-Amino-2'-deoxyuridine can be use in the preparation of labeled probes for DNA microarray analysis .
Cat. No.: HY-182358
CAS No.: 3116767-83-7
TMLZ-G46 is an orally active ZNF207 inhibitor with blood-brain barrier penetration ability, with a Kd value of 68 nM. TMLZ-G46 inhibits cancer cell proliferation, stemness, migration and invasion, induces G0/G1 cell cycle arrest and apoptosis, and suppresses colony formation. TMLZ-G46 can be used in glioma research .
Cat. No.: HY-P701518
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCAF16; DDB1- And CUL4-Associated Factor 16; Prev. C4orf30; Chromosome 4 Open Reading Frame 30; DDB1 And CUL4 Associated Factor 16; FLJ20280; DDB1; XPE-BF; Damage Specific DNA binding Protein 1; XAP-1; DNA Damage-binding Protein 1; XAP1; Xeroderma Pigment
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703472
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DCAF16; DDB1- And CUL4-Associated Factor 16; Prev. C4orf30; Chromosome 4 Open Reading Frame 30; DDB1 And CUL4 Associated Factor 16; FLJ20280; DDB1; XPE-BF; Damage Specific DNA binding Protein 1; XAP-1; DNA Damage-binding Protein 1; XAP1; Xeroderma Pigment
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703561
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DCAF8; WD Repeat-Containing Protein 42A; Prev. WDR42A; FLJ35857; H326; GAN2; DDB1- And CUL4-Associated Factor 8; DDB1 And CUL4 Associated Factor 8; WD Repeat Domain 42A; DDB1; XPE-BF; Damage Specific DNA binding Protein 1; XAP-1; DNA Damage-binding Protei
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P86737A
Synonyms: STAT3(phospho Y705); p-STAT3(phospho Y705); phospho-Stat3(pTyr705); STAT3(phospho-Tyr705); p-STAT3(Tyr705); phosphorylated Stat3(pTyr705); p-Stat3; Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of Transcription 3; STAT 3; STAT3_HUMAN.
Target:
Cat. No.: HY-187643
CAS No.: 304911-07-7
Research Areas:
CGC-11144 hydrochloride is a polyamine analog. CGC-11144 hydrochloride reduces the kinase activities of CDK4, CDK2 and CDK6, induces activation of the p53 pathway and p53-dependent p21 expression, and mediates cell cycle regulation, growth inhibition and apoptosis. CGC-11144 hydrochloride induces G1 phase cell cycle arrest, downregulates cyclin D1 and cyclin B1, upregulates cyclin E, induces dephosphorylation of pRb, and inhibits ERα-mediated transcriptional activity by disrupting the DNA binding of Sp1/Sp3 to the ERα promoter, while also stimulating activation of the JNK/AP-1 pathway. CGC-11144 hydrochloride can be used in research related to breast cancer, choroidal neovascularization and cancer .
Cat. No.: HY-P701520
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DCAF15; DDB1- And CUL4-Associated Factor 15; Prev. C19orf72; Chromosome 19 Open Reading Frame 72; DDB1 And CUL4 Associated Factor 15; MGC99481; DDB1; XPE-BF; Damage Specific DNA binding Protein 1; XAP-1; DNA Damage-binding Protein 1; XAP1; Xeroderma Pigme
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P81173
Synonyms: ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.
Cat. No.: HY-P703559
Purity: ≥ 95%, as determined by reducing SDS-PAGE
Synonyms: DCAF16; DDB1- And CUL4-Associated Factor 16; Prev. C4orf30; Chromosome 4 Open Reading Frame 30; DDB1 And CUL4 Associated Factor 16; FLJ20280; DDB1; XPE-BF; Damage Specific DNA binding Protein 1; XAP-1; DNA Damage-binding Protein 1; XAP1; Xeroderma Pigment
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-L008
738 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).
MCE provides 738 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.
Cat. No.: HY-182360
Target:
PERK Eukaryotic Initiation Factor (eIF) Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS) STING DNA/RNA Synthesis PD-1/PD-L1
Research Areas:
Cytisine-Platinum(IV) Prodrug-1 is a Pt(IV) prodrug incorporating the natural compound Cytisine (HY-N0175) with antiproliferative activity against tumor cells. Cytisine-Platinum(IV) Prodrug-1 promotes calcium transfer across the IP3R1-GRP75-VDAC1 axis to drive mitochondrial calcium overload. Cytisine-Platinum(IV) Prodrug-1 initiates unfolded protein response via PERK, eIF2α, ATF4, and CHOP to modulate Bcl-2 and Bax, triggering apoptosis. Cytisine-Platinum(IV) Prodrug-1 induces mitochondrial dysfunction, ROS production, reduced ATP synthesis, DNA damage, and S-phase cell cycle arrest. Cytisine-Platinum(IV) Prodrug-1 activates the cGAS-STING pathway, reduces PD-L1 expression, drives immunogenic cell death. Cytisine-Platinum(IV) Prodrug-1 exhibits high physiological stability, efficient cellular accumulation, and enhanced platinum-DNA binding, and inhibits tumor growth in mouse models with reduced systemic toxicity. Cytisine-Platinum(IV) Prodrug-1 can be used for the research of lung cancer .
Cat. No.: HY-P85597
Synonyms: 5''-deoxyribose-5-phosphate lyase Ku70; 5''-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA binding component of DNA-dependent proteinkinase complex; thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD; Ku antigen; Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; Thyroid-lupus autoantigen; TLAA; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC 6; XRCC6; XRCC6_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
