304911-07-7
Chemical Structure
CGC-11144 hydrochloride
- CAS No.: 304911-07-7
- Formula:C40H91ClN10
- Molecular Weight:747.67
SMILES: CCNCCCCNCCCCNCCCCNCCCCNC/C=C\CNCCCCNCCCCNCCCCNCCCCNCC.Cl.[10]
Biological Activity: CGC-11144 hydrochloride is a polyamine analog. CGC-11144 hydrochloride reduces the kinase activities of CDK4, CDK2 and CDK6, induces activation of the p53 pathway and p53-dependent p21 expression, and mediates cell cycle regulation, growth inhibition and apoptosis. CGC-11144 hydrochloride induces G1 phase cell cycle arrest, downregulates cyclin D1 and cyclin B1, upregulates cyclin E, induces dephosphorylation of pRb, and inhibits ERα-mediated transcriptional activity by disrupting the DNA binding of Sp1/Sp3 to the ERα promoter, while also stimulating activation of the JNK/AP-1 pathway. CGC-11144 hydrochloride can be used in research related to breast cancer, choroidal neovascularization and cancer[1][2][3][4][5][6].
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CGC-11144 hydrochloride | CGC-11144 hydrochloride is a polyamine analog. CGC-11144 hydrochloride reduces the kinase activities of CDK4, CDK2 and CDK6, induces activation of the p53 pathway and p53-dependent p21 expression, and mediates cell cycle regulation, growth inhibition and apoptosis. CGC-11144 hydrochloride induces G1 phase cell cycle arrest, downregulates cyclin D1 and cyclin B1, upregulates cyclin E, induces dephosphorylation of pRb, and inhibits ERα-mediated transcriptional activity by disrupting the DNA binding of Sp1/Sp3 to the ERα promoter, while also stimulating activation of the JNK/AP-1 pathway. CGC-11144 hydrochloride can be used in research related to breast cancer, choroidal neovascularization and cancer. | |||||||||||||||||||||
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References
- [1]. Huang Y, et al. Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells. Cancer Biol Ther. 2005 Sep;4(9):1006-13.
- [2]. Huang Y, et al. Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. The Journal of biological chemistry. 2006 Jul 14;281(28):19055-63.
- [3]. Fallahi-Sichani M, et al. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nature chemical biology. 2013 Nov;9(11):708-14.
- [4]. Mitchell JL, et al. Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs. Amino acids. 2007 Aug;33(2):291-7.
- [5]. Lima e Silva R, et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Investigative ophthalmology & visual science. 2005 Sep;46(9):3323-30.
- [6]. Carruthers LM, et al. Polyamine analogues: potent inducers of nucleosomal array oligomerization and inhibitors of yeast cell growth. The Biochemical journal. 2007 Aug 01;405(3):541-5.
