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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
344 Results for "
Imaging probe
" in MedChemExpress (MCE) Product Catalog:
Products (344)
344 Results for "Imaging probe" in MCE Product Catalog:
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Cat. No.: HY-D3084
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C-TPA is a fluorescent probe used for hypochlorite detection and bioimaging of lipid droplet polarity in cancer cells. For hypochlorite detection, when its derivative C-TPA-S is exposed to hypochlorite, an oxidative desulfurization reaction converts the thiocarbonyl group of C-TPA-S to the carbonyl group of C-TPA, thus restoring bright fluorescence from the almost non-fluorescent C-TPA-S. For bioimaging of lipid droplet polarity, the intramolecular charge transfer process between its Triphenylamine (HY-W011998) donor group and Coumarin (HY-N0709) acceptor group endows C-TPA with solvatochromism-it exhibits stronger fluorescence in less polar environments (such as lipid droplets in cancer cells) and weaker fluorescence in more polar environments (such as lipid droplets in normal cells), enabling the differentiation of cancer cells and cancer tissues from normal cells and normal tissues. The excitation wavelength of C-TPA is 405 nm, and the emission wavelengths used for cell and tissue imaging cover 425-475 nm and 500-550 nm; in solvents, its emission peak shifts from 494 nm in non-polar toluene to 528 nm in polar water .
Cat. No.: HY-D3094
CAS No.: 2687198-42-9
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TPE-SQ5 is a ratiometric Fluorescent probe for hypochlorite (ClO -) detection with a limit of detection of 5.6 nM. TPE-SQ5 exhibits high selectivity and high sensitivity towards ClO -. TPE-SQ5 can be oxidized by ClO - to form an epoxide, which quenches its deep red fluorescence; subsequently, the epoxide decomposes into a hemicyanine and a sulfonic acid-substituted oxindole, producing blue-green fluorescence to achieve a ratiometric response. TPE-SQ5 can form nanoparticles with Pluronic F-127 via the nanoprecipitation method, and these nanoparticles possess cell permeability. TPE-SQ5 has unique Ex/Em spectra in different solvents and nanoparticle forms, with emission peaks at 643 nm (380 nm excitation, 95% H2O/THF), 631 nm (564 nm excitation, DMSO), 652 nm (536 nm excitation, THF) and 630 nm (524 nm excitation, nanoparticles); the Ex/Em settings used for cell imaging are 488/550-650 nm (red channel) and 405/450-550 nm (green channel) .
Cat. No.: HY-D2465
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CY5-Dextran (MW60-80k) is a fluorescent probe formed by covalent conjugation of the cyanine dye Cy5 to dextran. It is a pH-insensitive fluid-phase endocytosis tracer (the pH of endosomal lumen is precisely quantified by the fluorescence ratio of FITC/Cy5). CY5-Dextran (MW60-80k) is internalized by cells via a clathrin-independent fluid-phase pinocytosis pathway, and is sequentially evidenced by early endosomes, late endosomes are transported to lysosomes. CY5-D I cannot pass through the limited pore size formed by uncoating of human rhinovirus type 2 (HRV2), but can be released into the neutral cytoplasm upon adenovirus-mediated endosomal rupture, thus distinguishing between the two viral modes of "pore-forming escape" and "lysis escape". CY5-Dextran (MW60) -80k) has an excitation wavelength of 635 nm, and it can also be used for time-lapse imaging of endocytosis dynamics of stromal cells in tissues such as rat salivary glands under in vivo two-photon microscopy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
