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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
344 Results for "
Imaging probe
" in MedChemExpress (MCE) Product Catalog:
Products (344)
344 Results for "Imaging probe" in MCE Product Catalog:
Cat. No.: HY-P5520
CAS No.: 2413262-74-3
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Cat. No.: HY-170779
CAS No.: 3078291-78-5
DOTA-NI-FAPI-04 is a FAP inhibitor (IC50 = 7.44 nM). By integrating FAP targeting with hypoxia-sensitive groups (nitroimidazole), DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes (such as 68Ga and 177Lu) through DOTA to produce radioactive probes ([68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact .
Cat. No.: HY-D1320
CAS No.: 1267539-32-1
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Cyanine5 azide chloride is a Fluorescent probe for cell-selective bacterial protein labeling, as well as a fluorescent dye for single-molecule imaging and dynamic tracking of intracellular organelles. Cyanine5 azide chloride can conjugate with the alkynyl side chain of propargylglycine incorporated into bacterial proteins by the engineered methionyl-tRNA synthetase variant PraRS via copper (I)-catalyzed azide-alkyne [3+2] cycloaddition reaction, thereby enabling in-gel fluorescent visualization of labeled proteins. Cyanine5 azide chloride can diffuse across cell membranes and undergo copper-free click reaction with DBCO-functionalized scAVD pre-bound to DBCO-functionalized biotin, forming fluorescent nanoprobes with enhanced brightness, photostability and localization accuracy, and exhibiting discrete photobleaching steps. The excitation wavelength of Cyanine5 azide chloride is Ex = 633 nm .
Cat. No.: HY-D3067
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ASSI-Leu is a novel AIE fluorescent probe based on an asymmetric tetraaryl imidazole skeleton, which can be used for ratiometric imaging detection of endogenous leucine aminopeptidase. ASSI-Leu contains an L-leucine-based recognition group that blocks the excited-state intramolecular proton transfer (ESIPT) in its 2-(2'-hydroxyphenyl) benzothiazole (HBT) skeleton, thereby generating an enol-form emission signal at Ex/Em = 365/417 nm. ASSI-Leu undergoes cleavage of the L-leucine group mediated by LAP to form ASSI-OH, which further activates aggregation-induced emission (AIE) and ESIPT, generating a keto-form emission signal at Ex/Em = 365/554 nm and producing a ratiometric fluorescent signal. ASSI-Leu enables real-time tracking of LAP in cancer cells and zebrafish models .\n
Cat. No.: HY-D3073
CAS No.: 2477607-64-8
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DXB-NIR is a push-pull dioxaboron fluorescent probe with solvatochromic properties, featuring high fluorescence brightness, photostability, and a large two-photon absorption cross-section. DXB-NIR exhibits Ex/Em of 550/620–780 nm (with two-photon excitation at 930 nm). DXB-NIR quantifies local polarity via the intensity ratio I (>640)/I (<640) between the far-red channel (<640 nm) and the near-infrared channel (>640 nm), and it can simultaneously label the plasma membrane, endoplasmic reticulum, and lipid droplets in live cells. DXB-NIR monitors the increase in local polarity of various cell compartments under conditions of cholesterol depletion, starvation, and oxidative stress. DXB-NIR can be used for polarity imaging of biological membranes and lipid droplets, as well as studies related to cellular stress .
Cat. No.: HY-D3186
CAS No.: 2163840-29-5
Cat. No.: HY-D3377
CAS No.: 1616953-95-7
Synonyms: LysoRhoNox
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HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for detecting Fe 2+ (ferrous iron ions), with excitation/emission wavelengths of Ex/Em = 550/575 nm. HMRhoNox-M exists in a non-fluorescent spirocyclic closed conformation under physiological pH conditions. Fe 2+ triggers the deoxidation of its N-oxide group, shifting the equilibrium toward the fluorescent quinone-type (TMHMR) open conformation. HMRhoNox-M shows selectivity for Fe 2+ over other metal ions, as well as biologically relevant reactive oxygen species, reactive sulfur species, reactive nitrogen species and reducing agents. HMRhoNox-M can penetrate cell membranes and localize to lysosomes, enabling the imaging of intracellular Fe 2+ fluctuations, transferrin-mediated labile iron accumulation, and lysosomal Fe 2+ changes associated with ferroptosis .
Cat. No.: HY-D3391
Cat. No.: HY-D3418
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BOD-Tz-TMR is a fluorescent probe used for nitric oxide (NO) detection and atherosclerotic plaque imaging.BOD-Tz-TMR has a detection limit of 31 nM for NO. BOD-Tz-TMR functions via Förster resonance energy transfer (FRET) and bioorthogonal reactions, in which the tetrazine linker quenches fluorescence through the energy transfer to dark state (ETDS) mechanism. The interaction of BOD-Tz-TMR with NO triggers a ratiometric shift in fluorescence from BODIPY (Ex/Em: 488 nm/512 nm, green channel) to TMR (Em: 592 nm, red channel). BOD-Tz-TMR labels macrophages through a bioorthogonal reaction with BCN, enabling its targeted accumulation at atherosclerotic plaque sites to detect endogenous NO associated with lesion progression. BOD-Tz-TMR can be used in studies related to atherosclerosis .
Cat. No.: HY-D3428
CAS No.: 2863678-02-6
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Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
LJ-2P is an NIR-II small-molecule fluorescent probe with fibrin/fibrinogen affinity. LJ-2P can bind coagulation-related proteins and restrict dye molecular motion, thereby enhancing local fluorescence for high-contrast imaging of bleeding and blood clots in vivo. LJ-2P can also co-precipitate with Ca 2+ to form LJ-2P nanoparticles, significantly enhancing NIR-II luminescence through the precipitation-enhanced emission (PEE) mechanism. LJ-2P can be used for research on bleeding disorders and breast cancer. LJ-2P exhibits dual-modal emission properties (Ex/Em ≈740/945 nm or 740/1066 nm) .
Cat. No.: HY-D3105
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DCA is a Fluorescent probe for visualization of phase behavior in ER membranes. DCA is an ER-targeting, polarity-responsive NIR ratiometric probe, with its p-toluenesulfonamide group responsible for ER localization; its sensitivity to polarity relies on its donor-π-acceptor (D-π-A) structure, where aniline acts as the donor and dicyanomethylene acts as the acceptor, driving an intramolecular charge transfer (ICT) process upon excitation. In environments with low polarity, such as the closely packed, low water content ERₒ phase of ER membranes, DCA emits at a shorter wavelength, while in high polarity environments like the loosely packed, higher water content ERd phase, ICT leads to a red-shifted emission, allowing discrimination of the two phases via dual NIR emission colors and ratiometric imaging. Ex/Em = 488/570–620 nm and 488/665–735 nm; additional excitation/emission pairs include Ex/Em = 488/631 nm in low polarity 1,4-dioxane and Ex/Em = 488/677 nm in 1,4-dioxane with 30% water, the higher polarity condition. It shows a large Stokes shift of ~170 nm, and pH, viscosity, and biologically relevant species including Cys, GSH, H₂O₂, and metal ions do not exert marked interference on its fluorescence spectra[1].
Cat. No.: HY-D3080
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CR-1 is a ratiometric photoacoustic (PA) probe for in-situ real-time imaging of Zn 2+ in deep living tissues. CR-1 is formed by coupling the near-infrared cyanine dye IR825 with the Zn 2+ ligand tris (2-pyridylmethyl) amine (TMPA). Upon binding to Zn 2+, the five N atoms on TMPA coordinate with Zn 2+, leading to double bond rearrangement of IR825 and attenuation of its π-electron conjugated system. The absorption peak of CR-1 blue-shifts from 710 nm to 532 nm, enabling quantitative detection of Zn 2+ via the PA532/PA710 ratio. Free CR-1 generates a strong PA signal at 710 nm, while CR-1 bound to Zn 2+ produces a strong PA signal at 532 nm .
Cat. No.: HY-D3090
CAS No.: 2757682-04-3
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NRLD is a lipid droplet-targeting solvatochromic fluorescent probe developed based on Nile Red (HY-D0718), which can target lipid droplets and sense the non-polar lipid microenvironment inside lipid droplets. NRLD exhibits superior lipid droplet-targeting selectivity compared to the parent Nile Red dye in HeLa cell imaging. NRLD achieves detection relying on the solvatochromic effect generated by excited-state charge transfer, and its emission wavelength shifts according to the local polarity changes of the microenvironment it locates in: the more compact and ordered the lipid packing and the lower the environmental polarity, the more blue-shifted the emission; the looser the lipid packing or the stronger the hydration and the higher the environmental polarity, the more red-shifted the emission. NRLD shows blue shift in the non-polar oil core of lipid droplets and red shift in high-polarity environments such as phosphate buffer .
Cat. No.: HY-W035399S
Cat. No.: HY-W035399S1
CAS No.: 2708340-91-2
Cat. No.: HY-Y1804S
CAS No.: 2714413-18-8
Cat. No.: HY-D3074
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TCM-4COOH is an AIE-active fluorescent probe for calcium ions. TCM-4COOH relies on aggregation-induced emission activity, and its carboxyl chelating group can bind to Ca 2+ and Mg 2+ to form insoluble aggregates, triggering fluorescence enhancement via restricting intramolecular motion (Ex/Em = 477/603 nm). TCM-4COOH shows pH independence in physiological environments (pH 4-9), can be strongly activated at Ca 2+ concentrations ranging from low nM to mM, and has a stronger binding ability to Ca 2+ than to Mg 2+. TCM-4COOH, as its acetoxymethyl ester derivative TCM-AM, can penetrate cell membranes for intracellular detection. TCM-4COOH can be used for imaging of cellular calcium overload, detection of bone microcracks, and studies related to calcium-rich biological environments .
Cat. No.: HY-D3088
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CQPP is a Fluorescent probe designed for monitoring polarity changes in the cellular microenvironment, including polarity tracking of lipid droplets/nuclei during ferroptosis. CQPP exhibits ratiometric fluorescence emission and fluorescence lifetime variations in response to polarity changes; a nonpolar environment stimulates fluorescence from the locally excited (LE) state, while a polar environment drives solvation relaxation to the intramolecular charge transfer (ICT) state, which attenuates the LE emission at ~470 nm and simultaneously enhances the ICT emission at ~670 nm. CQPP binds to intranuclear DNA through electrostatic interactions and hydrogen bonds in the DNA minor groove, which enhances its emission at ~670 nm and prolongs its fluorescence lifetime. CQPP can simultaneously target lipid droplets (green LE fluorescence) and the nucleus (red ICT fluorescence). The detection wavelengths of CQPP are Ex/Em = 405/470 nm and Ex/Em = 405/670 nm, and it also supports fluorescence lifetime imaging via 810 nm two-photon excitation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
