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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
344 Results for "
Imaging probe
" in MedChemExpress (MCE) Product Catalog:
Products (344)
344 Results for "Imaging probe" in MCE Product Catalog:
Cat. No.: HY-D3109
CAS No.: 148043-22-5
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pH-Ap-1 is a fluorescent probe used for ratiometric monitoring of pH fluctuations during autophagy in living cells, and it can detect intracellular pH changes in the autophagy process. For fluorescence detection of pH-Ap-1, its excitation wavelength is 475 nm, with an emission wavelength of 538 nm under alkaline conditions and 645 nm under acidic conditions. For intracellular imaging, excitation is performed at 488 nm: the emission light ranging from 500-550 nm is collected via the green channel corresponding to 538 nm, while the emission light ranging from 625-750 nm is collected via the red channel corresponding to 645 nm. pH-Ap-1 exhibits excellent photostability and chemical stability .
Cat. No.: HY-D3123
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Ac-MtFluNox is a mitochondria-targeted Fluorescent probe that can be used for the selective detection of labile Fe (II). Ac-MtFluNox can enter living cells, where intracellular esterases cleave its acetyl protecting group to generate activated MtFluNox. Ac-MtFluNox functions through an Fe (II)-mediated deoxygenation mechanism of its amine N-oxide group, which eliminates the fluorescence quenching effect and oxidizes Fe (II) to Fe (III) to deplete the catalytically active Fe (II) pool. A FITC filter set (excitation 465-500 nm, emission 516-556 nm) is used for live-cell imaging. Ac-MtFluNox can be applied to studies related to myocardial ferroptosis .
Cat. No.: HY-D3192
CAS No.: 2028316-07-4
Cat. No.: HY-D3443
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NR-HOCl-TFMU is a HOCl-gated phosphonite fluorescent probe based on the Nebraska Red scaffold. NR-HOCl-TFMU undergoes HOCl-triggered oxidative ring-opening of the spirocyclic thioether and phosphonite hydrolysis to synchronously release the near-infrared reporter group NR666-MSA (Ex 666 nm/Em 698 nm) and the cargo TFMU (Ex 405 nm/Em 510 nm) . NR-HOCl-TFMU enables HOCl-selective fluorescence imaging and cargo release monitoring in vitro, in live cells and in vivo, and exerts gated selective cytotoxicity in HOCl-positive cells. NR-HOCl-TFMU can be used for studies related to acute myeloid leukemia .
Cat. No.: HY-DY1111
CAS No.: 1539318-40-5
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DFHBI-2T solution is a membrane-permeable, RNA aptamer-activated fluorescent probe (Ex/Em=500 nm/523 nm), with a Kd value of 1300 nM for the RNA aptamer Spinach2. DFHBI-2T solution binds to Spinach2, converting the fluorophore to a fluorescent state, stabilizing its planar structure to facilitate the radiative fluorescence decay pathway, and forming a complex with red-shifted excitation and emission peaks. DFHBI-2T solution can be used for RNA imaging in live cells. It is also applicable to research related to fragile X-associated tremor/ataxia syndrome .
Solvent and concentration: DMSO: 5 mM
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-DY1120
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ZY-2 (solution) is a fluorescent probe targeting pyruvate kinase M2 (PKM2) with an excitation wavelength of 419 nm. ZY-2 (solution) significantly activates purified PKM2 protein. ZY-2 (solution) exhibits enhanced fluorescence emission in low-polarity or high-viscosity environments. ZY-2 (solution) enables highly sensitive and selective fluorescence imaging of PKM2 in live PKM2-positive cancer cells, with no significant side effects on cell viability within its effective concentration range. ZY-2 (solution) can be used for cervical cancer research .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-W011696
CAS No.: 112-90-3
Synonyms: cis-1-Amino-9-octadecene, 80-90%
Cat. No.: HY-W400925
CAS No.: 1481447-40-8
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Sulfo-Cy5-N3 is an azide-functionalized sulfonated cyanine 5 Fluorescent dye and also serves as click chemistry coupling reagent. Sulfo-Cy5-N3 undergoes copper (I)-catalyzed azide-alkyne cycloaddition with alkyne-functionalized antibody constructs and peptide probes for site-selective fluorescent labeling. Sulfo-Cy5-N3 also acts as an emission dye for STORM super-resolution imaging. Sulfo-Cy5-N3 is applicable to the study of HER2-positive breast cancer .
Cat. No.: HY-D3120
CAS No.: 2246946-53-0
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LysoAIE2 is a Fluorescent probe for lysosomal viscosity detection and live-cell imaging. Its detection mechanism relies on the aggregation-induced emission effect: it exhibits only weak fluorescence in non-viscous media; in viscous environments, restricted intramolecular motion inhibits non-radiative energy dissipation pathways, thereby significantly enhancing fluorescence intensity. It achieves specific targeting of lysosomes through the proton acceptor property of its indole ring structure, while its hydroxyl group endows it with excellent water solubility. This probe is basically unaffected by microenvironmental polarity and pH within the range of pH 4.0 to pH 8.0, which avoids interference from these factors in viscosity measurement. LysoAIE2 has an emission wavelength of 570 nm. It can be used to monitor lysosomal viscosity changes during processes such as Dexamethasone (HY-14648)-induced lysosomal migration and starvation-induced mitophagy in live cells; at concentrations up to 40 μM, cell viability remains above 80%, demonstrating excellent biocompatibility .
Cat. No.: HY-D3187
CAS No.: 2484831-02-7
Cat. No.: HY-176834
CAS No.: 110925-86-5
3-Deoxy-3-fluoro-D-fructose (Compound 12) is a derivative of 2,5-Anhydro-D-mannitol. 3-Deoxy-3-fluoro-D-fructose is a selective probe of Hexose transporter 5 (GLUT5). 3-Deoxy-3-fluoro-D-fructose inhibits the transport of D-fructose labeled with 14C by GLUT5 with IC50s of 1.16 and 2.37 µM in EMT-6 and MCF-7 cells. 3-Deoxy-3-fluoro-D-fructose can be used for positron emission tomography (PET) imaging of cancers .
Cat. No.: HY-DY1089
CAS No.: 797785-10-5
Solvent and concentration: DMSO: 5 mM
Cat. No.: HY-D3440
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CDPP-2PF6 is a dicationic aggregation-induced emission (AIE) fluorescent probe used for imaging of cell membranes, migrasomes, and PIP2 lipid vesicles, as well as for long-term imaging of cell membranes and migrasomes. CDPP-2PF6 relies on electrostatic and hydrophobic interactions to achieve dual-mode membrane anchoring, with the PF6 - counterion enhancing lipophilicity and generating fluorescence through restriction of intramolecular motion (RIM). When CDPP-2PF6 accumulates in phosphoinositide-rich membrane regions, RIM suppresses non-radiative decay pathways. Due to the electrostatic interaction between the positively charged core of CDPP-2PF6 and the high negative charge density of PIP2, CDPP-2PF6 exhibits a strong preferential affinity for phosphatidylinositol 4,5-bisphosphate (PIP2). The fluorescence localization of CDPP-2PF6 depends on intact lipid microdomain structures and enables real-time tracking of membrane remodeling processes (Ex/Em = 450/760 nm) .
Cat. No.: HY-165426
CAS No.: 3031522-14-9
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HB-230 is a Transglutaminase-2 (TG2) (human IC50 = 4.9 μM) inhibitor and a selective fluorescent imaging probe for active TG2 localization. HB-230 modifies TG2 Cys277 to sustain the enzyme open conformation. HB-230 forms a ternary complex with TG2 and α2-macroglobulin, undergoes receptor-mediated endocytosis, and trafficks directly to lysosomes without early/late endosome fusion. HB-230 exhibits TG2 activity-dependent and α2-macroglobulin-dependent uptake. HB-230 can be used for the research of celiac disease, (Ex/Em = 649/665 nm) .
Cat. No.: HY-D0920
CAS No.: 166196-17-4
Cat. No.: HY-D1991
CAS No.: 906664-68-4
Cat. No.: HY-D3108
CAS No.: 2569032-08-0
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BV-1 is a fluorescent probe for viscosity detection and imaging in living cells. BV-1 can be used to detect changes in intracellular viscosity and mitochondrial viscosity in living cells. BV-1 responds to environmental viscosity via a molecular rotor mechanism. In a low-viscosity environment, the centrally located unsaturated structure induces a twisted intramolecular charge transfer (TICT) state and promotes non-radiative transitions, resulting in fluorescence quenching; when viscosity increases, molecular rotation is restricted, the TICT state is attenuated, and fluorescence is enhanced with a red shift. BV-1 can be used for real-time monitoring of changes in cytoplasmic viscosity and the viscosity increase during cell apoptosis. Ex/Em = 480/570 nm .
Cat. No.: HY-D3189
CAS No.: 2370825-44-6
Cat. No.: HY-D3351
CAS No.: 2668963-61-7
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PNO1 is a fluorescent probe for pulmonary fibrosis detection. The detection mechanism of PNO1 relies on sensing upregulated nitric oxide (NO) in the pulmonary fibrosis (PF) microenvironment. PNO1 contains an aniline group that reacts with NO or its derivatives under acidic conditions to form an N-nitrosylated intermediate, which is subsequently converted into a diazonium salt and undergoes deamination, eliminating the intramolecular electron transfer quenching effect and triggering a fluorescence turn-on response. The excitation wavelength of PNO1 includes 545 nm in in vitro solution studies, while an excitation range of 520-550 nm is used for cell, tissue and in vivo imaging; its emission wavelength centers at 572 nm in the unreacted state, and shifts to 559 nm with enhanced fluorescence intensity upon binding to NO. PNO1 can be used for pulmonary fibrosis research .
Cat. No.: HY-P10792A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
