166196-17-4
Chemical Structure
TOTO-3
- CAS No.: 166196-17-4
- Formula:C53H62I4N6S2
- Molecular Weight:1354.85
IUPAC Name: 1-(3-((3-(dimethyl(3-(4-((1E,3E)-3-(3-methylbenzo[d]thiazol-2(3H)-ylidene)prop-1-en-1-yl)quinolin-1-ium-1-yl)propyl)ammonio)propyl)dimethylammonio)propyl)-4-((1E,3Z)-3-(3-methylbenzo[d]thiazol-2(3H)-ylidene)prop-1-en-1-yl)quinolin-1-ium iodide
InChIKey: IUDMYNMSADWSKL-UHFFFAOYSA-J
SMILES: CN1C2=CC=CC=C2S/C1=C\C=C\C3=CC=[N+](CCC[N+](C)(CCC[N+](C)(CCC[N+]4=CC=C(/C=C/C=C5SC6=C(C=CC=C6)N/5C)C7=C4C=CC=C7)C)C)C8=C3C=CC=C8.[I-].[I-].[I-].[I-]
Biological Activity: TOTO-3 is a cyanine nucleic acid intercalating fluorescent probe that binds to both RNA and DNA (Ex=642 nm, Em=660 nm). TOTO-3 cannot enter intact cells, but can penetrate cells with permeabilized plasma membranes, staining cytoplasmic RNA and nucleoli to distinguish intact cells from damaged ones. TOTO-3 is taken up by macrophages in an ultrasound-independent manner. TOTO-3 accumulates in tumor cells via ultrasound-mediated enhancement of plasma membrane permeability. TOTO-3 supports optical imaging for real-time assessment of plasma membrane integrity, nucleic acid detection, and monitoring of ultrasound-mediated intracellular delivery processes. TOTO-3 is applicable to studies related to rectal cancer[1][2].
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TOTO-3 | 85.0% | TOTO-3 is a cyanine nucleic acid intercalating fluorescent probe that binds to both RNA and DNA (Ex=642 nm, Em=660 nm). TOTO-3 cannot enter intact cells, but can penetrate cells with permeabilized plasma membranes, staining cytoplasmic RNA and nucleoli to distinguish intact cells from damaged ones. TOTO-3 is taken up by macrophages in an ultrasound-independent manner. TOTO-3 accumulates in tumor cells via ultrasound-mediated enhancement of plasma membrane permeability. TOTO-3 supports optical imaging for real-time assessment of plasma membrane integrity, nucleic acid detection, and monitoring of ultrasound-mediated intracellular delivery processes. TOTO-3 is applicable to studies related to rectal cancer. | ||||||||||||||||||||
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References
- [1]. Sultana M, et al.. A review on experimental chemically modified activated carbon to enhance dye and heavy metals adsorption. Cleaner Engineering and Technology. 2022;6:100382.
- [2]. Duval RE, et al. Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells. Oncol Rep. 2008;19(1):145-149. [Content Brief]
