2413262-74-3
Chemical Structure
GB-6
- CAS No.: 2413262-74-3
- Formula:C32H45N11O8
- Molecular Weight:711.77
InChIKey: MRBDDQRPZZFCHW-LFBFJMOVSA-N
SMILES: N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=CC=C(O)C=C21)C(NCCC(N[C@@H](CCC)C(NCC(N[C@@H](CC3=CNC=N3)C(N)=O)=O)=O)=O)=O)=O
Biological Activity: GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].
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GB-6 | GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects. | |||||||||||||||||||||
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