D-Lysine-d4 monohydrochloride
D-Lysine-d4 monohydrochloride is the d4 D-Lysine monohydrochloride (HY-Y1804). D-Lysine monohydrochloride is the D-enantiomer of L-Lysine (HY-N0469). D-Lysine monohydrochloride is metabolically inert and not utilized for protein synthesis by mammalian ribosomes. D-Lysine monohydrochloride blocks renal uptake of 111In/90Y-Octreotide (HY-P0036)-based probes without inhibiting uptake by tumor/receptor tissues, and thus acts as a renoprotective agent in diagnostic imaging and peptide receptor radionuclide therapy (PRRT). D-Lysine monohydrochloride specifically inhibits the early steps of non-enzymatic glycation by competing with glucose via its free amino group, theoretically, it can serve as a glycation competitor that "does not interfere with protein synthesis" under chronic hyperglycemia in diabetes. D-Lysine monohydrochloride can be used in research related to cancer and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 2714413-18-8
- Formula: C6H11D4ClN2O2
- Molecular Weight:186.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2714413-18-8
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Molecular Weight 186.67
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Formula C6H11D4ClN2O2
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SMILES
NCC([2H])([2H])C([2H])([2H])C[C@@H](N)C(O)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Mondal D, et, al. Synthesis and antibacterial properties of carbohydrate-templated lysine surfactants. Carbohydr Res. 2011 Apr 1;346(5):588-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-Lysine-d4 monohydrochloride Related Classifications
HY-Y1804S Related Classifications
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- D-Lysine-d4 monohydrochloride
- 2714413-18-8
- Isotope-Labeled Compounds
- Drug Isomer
- renal tubular reabsorption
- human albumin
- isolated glomerular basement membrane
- IgG
- ketoamine formation
- non-enzymic protein glycation
- diabetes mellitus
- collagen
- radiolabeled octreotide analogs
- somatostatin receptor-positive organs
- Inhibitor
- inhibitor
- inhibit