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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
Flt1
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "Flt1" in MCE Product Catalog:
Cat. No.: HY-50751R
CAS No.: 796967-16-3
Synonyms: ABT-869 (Standard); AL-39324 (Standard)
Linifanib (Standard) is the analytical standard of Linifanib. This product is intended for research and analytical applications. Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis [1] .
Cat. No.: HY-110272
CAS No.: 212142-18-2
Synonyms: PTK787 succinate; ZK-222584 succinate; CGP-79787 succinate
Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively [1].
Cat. No.: HY-P990541
Target:
Research Areas:
Cat. No.: HY-13049R
CAS No.: 857036-77-2
Synonyms: AZD-2171 maleate (Standard)
Target:
Research Areas:
Cediranib (maleate) (Standard) is the analytical standard of Cediranib (maleate). This product is intended for research and analytical applications. Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
Cat. No.: HY-10205R
CAS No.: 288383-20-0
Synonyms: AZD2171 (Standard)
Target:
Research Areas:
Cediranib (Standard) is the analytical standard of Cediranib. This product is intended for research and analytical applications. Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
Cat. No.: HY-168115
CAS No.: 2648279-77-8
Multi-kinase inhibitor 4 (compound 14) is an orally active inhibitor of FLT1, KDR, FLT3, FLT4, PDGFRα, PDGFRβ, with IC50s of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, 0.89 nM. Multi-kinase inhibitor 4 plays an important role in cancer research [1].
Cat. No.: HY-168114
CAS No.: 2648279-76-7
Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity [1].
Cat. No.: HY-123586
CAS No.: 791807-02-8
L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma [1] .
Cat. No.: HY-181754
CAS No.: 1005781-50-9
Target:
Research Areas:
TPKI-39 is a DDR1, DDR2, and FLT1 inhibitor, with a human DDR1 IC50 of 380 nM, human DDR1 Ka of 24 nM, human DDR2 IC50 of 120 nM, human FLT1 IC50 of 65 nM, and human FLT1 Ka of 91 nM.TPKI-39 inhibits DDR1 enzymatic activity and autophosphorylation, DDR2 enzymatic activity, and FLT1 enzymatic activity in cells.TPKI-39 inhibits collagen-induced DDR1 autophosphorylation in cells [1].
Cat. No.: HY-P78537
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P78230
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P73552
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Rat
Source:
HEK293
Cat. No.: HY-P73553
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73554
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P705895
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Human
Source:
E. coli
Cat. No.: HY-P73065
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P73064
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1; Tyrosine-Protein Kinase Receptor Flt; Soluble Flt1 Variant E15a; Fms-Like Tyrosine Kinase 1; P19Flt1; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); P28Flt1; Fms Related Tyrosine Kinase 1; FRT; Fms Related Receptor Tyrosine Kinase 1; VEGFR-1
Species:
Human
Source:
HEK293
Cat. No.: HY-P705602
Purity: ≥ 75%, as determined by reducing SDS-PAGE.
Synonyms: Flt1; Tyrosine-Protein Kinase FRT; Prev. Flt; Flt-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1; Tyrosine-Protein Kinase Receptor Flt; Soluble Flt1 Variant E15a; Fms-Like Tyrosine Kinase 1; P19Flt1; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); P28Flt1; Fms Related Tyrosine Kinase 1; FRT; Fms Related Receptor Tyrosine Kinase 1; VEGFR-1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-10517R
CAS No.: 252916-29-3
Synonyms: SU6668 (Standard); TSU-68 (Standard)
Orantinib (Standard) is the analytical standard of Orantinib (HY-10517). This product is intended for research and analytical applications. Orantinib (SU6668; TSU-68) is a multi-targeted receptor tyrosine kinase inhibitor with Kis of 2.1 μM, 8 nM and 1.2 μM for Flt-1, PDGFRβ and FGFR1, respectively.
Cat. No.: HY-18692
CAS No.: 597544-21-3
Research Areas:
Multi-kinase-IN-12 is a non-selective multi-target inhibitor, with IC50 values against human targets as follows: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and α2 subunit of AMPK 0.041 μM. Multi-kinase-IN-12 can be used in research related to solid tumors [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
