212142-18-2
212142-18-2
Chemical Structure
Vatalanib succinate
Synonym(s): PTK787 succinate; ZK-222584 succinate; CGP-79787 succinate
- CAS No.: 212142-18-2
- Formula:C24H21ClN4O4
- Molecular Weight:464.90
IUPAC Name: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate
InChIKey: LLDWLPRYLVPDTG-UHFFFAOYSA-N
SMILES: ClC(C=C1)=CC=C1NC2=C3C(C=CC=C3)=C(CC4=CC=NC=C4)N=N2.OC(CCC(O)=O)=O
Biological Activity: Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1].
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Vatalanib succinate | Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively. | |||||||||||||||||||||
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References
Keywords
