Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
NH2-PEG3
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "NH2-PEG3" in MCE Product Catalog:
Target:
Research Areas:
NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-P11270
CAS No.: 2843676-09-3
Synonyms: BGM0504; BG128
Target:
Research Areas:
Cat. No.: HY-169150A
CAS No.: 2241669-80-5
Research Areas:
JQ-1 carboxylic acid-PEG3-C2-NH2 (hydrochloride) is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT .
Cat. No.: HY-128716
CAS No.: 2093416-31-8
Synonyms: Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30
Research Areas:
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
Cat. No.: HY-169089A
Target:
Research Areas:
Cat. No.: HY-P10319
Target:
Research Areas:
Cat. No.: HY-W800618
CAS No.: 2055024-62-7
Target:
Research Areas:
NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
Cat. No.: HY-156316
CAS No.: 2141976-29-4
Target:
Research Areas:
SCO-PEG3-NH2 is a cleavable ADC Linker containing 3 PEG units. SCO-PEG3-NH2 can be used as a copper-free click chemical reagent for catalyst-free click reactions.
Cat. No.: HY-156316A
Target:
Research Areas:
SCO-PEG3-NH2 formate is a cleavable ADC Linker containing 3 PEG units. SCO-PEG3-NH2 formate can be used as a copper-free click chemical reagent for catalyst-free click reactions .
Cat. No.: HY-134712
CAS No.: 3026715-57-8
Target:
Research Areas:
Methylacetamide-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-130965
CAS No.: 1957236-10-0
Research Areas:
Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
Cat. No.: HY-130965B
CAS No.: 2983036-20-8
Research Areas:
Thalidomide-PEG3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-PEG3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
Cat. No.: HY-W348348
CAS No.: 863973-20-0
Target:
Research Areas:
CbzNH-PEG3-CH2CH2NH2 is a PEG linker containing an amine group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
Cat. No.: HY-189146
Research Areas:
HDTAC EGFR Degrader-1 is an EGFR HDTAC (hypoxia-activated targeted protein degradation chimera) degrader with a DC50 of 1.76 μM. HDTAC EGFR Degrader-1 consists of a linker, a tumor hypoxia-activated group (HAG, a group that generates ROS under tumor hypoxic conditions), and an EGFR ligand. HDTAC EGFR Degrader-1 drives EGFR degradation through the proteasomal pathway. HDTAC EGFR Degrader-1 downregulates Caspase-3 under hypoxic conditions. HDTAC EGFR Degrader-1 can be used in research on non-small cell lung cancer harboring EGFR mutations (EGFR ligand: FAAH-IN-2 (HY-79511); HAG: Thalidomide-O-COOH (HY-103597); linker: NH2-PEG3 (HY-W007545)) .
Cat. No.: HY-W190756
CAS No.: 132316-46-2
Cat. No.: HY-P10319A
Cat. No.: HY-P11488
Research Areas:
Cat. No.: HY-P11485
Research Areas:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
