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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
Neolignans
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "Neolignans" in MCE Product Catalog:
Cat. No.: HY-N11934
CAS No.: 895543-36-9
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Cat. No.: HY-147535
CAS No.: 503323-06-6
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively .
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
Cat. No.: HY-N18096
CAS No.: 675881-22-8
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Cat. No.: HY-N1726
CAS No.: 57457-99-5
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Cat. No.: HY-N9303
CAS No.: 67920-48-3
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Cat. No.: HY-N19797
CAS No.: 845673-17-8
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Cat. No.: HY-N21756
CAS No.: 2760199-11-7
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Cat. No.: HY-N18294
CAS No.: 137196-25-9
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Cat. No.: HY-N16768
CAS No.: 193153-52-5
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Cat. No.: HY-N17764
CAS No.: 1931100-79-6
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Cat. No.: HY-N18301
CAS No.: 69506-79-2
Cat. No.: HY-180820
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Dimethyl bisphenolate (Compound DMB) is a natural neolignan derivative with orally active anti-tumor activity. Dimethyl bisphenolate can inhibit cancer cells proliferation, invasion and migration. Dimethyl bisphenolate can activate the p53 signaling pathway, upregulate the expression of p21 protein, inhibit the activity of the CDK1-cyclin B1 complex, and cause cells to stall at the G2/M phase. Dimethyl bisphenolate can induce ROS production, upregulate pro-apoptotic proteins Noxa and Bim, downregulate anti-apoptotic protein Bcl-2, activate caspase-9 and caspase-3, and ultimately induce cell apoptosis. Dimethyl bisphenolate can be used for research of glioblastoma .
Cat. No.: HY-N16980
CAS No.: 2292113-33-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
