Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Nrf2/nuclear factor
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Nrf2/nuclear factor" in MCE Product Catalog:
Cat. No.: HY-14909R
CAS No.: 218600-44-3
Synonyms: CDDO (Standard); RTA 401 (Standard)
Research Areas:
Bardoxolone (Standard) is the analytical standard of Bardoxolone (HY-14909). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury .
Cat. No.: HY-117993
CAS No.: 1639965-26-6
Target:
Research Areas:
MIND4 is a neuroprotective thiozoline compound that inhibits the deacetylase SIRT2. MIND4 is also an inducer and activator of the nuclear factor NRF2. MIND4 can induce NRF2 activation in neurons and non-neuronal cells and reduce the production of reactive oxygen and nitrogen intermediates .
Cat. No.: HY-N10431
Category:
Target:
Cat. No.: HY-14649S5
CAS No.: 154461-49-1
Synonyms: Vitamin A acid-d3; all-trans-Retinoic acid-d3; ATRA-d3
Cat. No.: HY-14649S6
CAS No.: 3041101-53-2
Synonyms: Vitamin A acid-d3-1; all-trans-Retinoic acid-d3-1; ATRA-d3-1
Category:
Cat. No.: HY-P7S1785
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; nuclear factor, erythroid derived 2, like 2; NFE2L2; Nrf2
Species:
Human
Source:
E. coli
Cat. No.: HY-P84609A
Synonyms: NFE2L2; Nrf2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2
Cat. No.: HY-P72308A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; nuclear factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP Transcription factor 2; nuclear factor, Erythroid Derived 2, Like 2; Nrf2; nuclear factor Erythroid-Derived 2-Like 2; nuclear factor Erythroid 2-Related factor 2; nuclear factor, Erythroid 2-Like 2; Nrf-2; NFE2-Related factor 2; nuclear factor, Erythroid 2 Like 2; IMDDHH; NF-E2-Related factor 2; Nrf-2; nuclear factor Erythroid-Derived 2-Like 2 Transcript Variant 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P80841A
Synonyms: NFE2L2; Nrf2; nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; nuclear factor; erythroid derived 2; like 2
Cat. No.: HY-P704943
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; nuclear factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP Transcription factor 2; nuclear factor, Erythroid Derived 2, Like 2; Nrf2; nuclear factor Erythroid-Derived 2-Like 2; nuclear factor Erythroid 2-Related factor 2; nuclear factor, Erythroi
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-180112
Research Areas:
SH543 is a potent anti-osteoporosis agent. SH543 inhibits nuclear factor κB ligand (RANKL)-induced osteoclastogenesis with an IC50 of 3.3 nM. SH543 directly binds to KEAP1, activates the Nrf2-HO-1 antioxidant pathway, reduces ROS levels, and inhibits PI3K-AKT and MAPK signaling pathways. SH543 attenuates pathological bone loss in ovariectomized mice. SH543 can be used for osteoporosis research .
Cat. No.: HY-184846
CAS No.: 3025286-29-4
Target:
Research Areas:
PROTAC Nrf2 degrader-1 is a PROTAC degrader targeting Nrf2, with IC50 values of 10 nM and 3 nM in A549 cells and LK-2 cells, respectively. PROTAC Nrf2 degrader-1 can be used in cancer research .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
