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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
Peripheral lymphocytes
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "Peripheral lymphocytes" in MCE Product Catalog:
Cat. No.: HY-W423502
CAS No.: 68489-14-5
Synonyms: Menthane carboxamidoethyl acetate
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WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient .
Cat. No.: HY-NP187
Synonyms: PWM
Cat. No.: HY-NP0138
Synonyms: PNA (Fluorescein)
Cat. No.: HY-12355S
CAS No.: 2104759-32-0
Synonyms: BAF-312-d11
Cat. No.: HY-P991543
CAS No.: 339181-10-1
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BTI-322 is a human IgG1κ antibody directed against the CD2 antigen on T cells and NK cells. BTI-322 can block primary and memory alloantigen proliferative responses in vitro. BTI-322 recognizes over 90% of E-rosette-forming peripheral blood lymphocytes and T-cell leukemias. BTI-322 has immunosuppressive activity. BTI-322 effectively inhibits T cell responses in vitro to allogeneic cells. BTI-322 can be used as a T-cell deplting agent. BTI-322 can be studied in research for renal allograft rejection and steroid-refractory acute graft-versus-host disease .
Cat. No.: HY-118917
CAS No.: 297730-05-3
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VX-148 is an orally active immunosuppressant, which is a non-competitive inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor with Ki values for IMPDH Ⅱ and IMPDH Ⅰ of 6 and 14 nM respectively. VX-148 can significantly inhibit the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated by T-cell mitogen (PHA) or B-cell mitogen (SPAS). VX-148 has high selectivity for lymphocytes (such as L1210, Jurkat T cells, and Raji B cells), but has no significant toxicity to non-lymphoid cells. VX-148 can inhibit antibody responses in mouse models and significantly prolong the survival time of transplanted skin in allogeneic skin transplantation models. VX-148 can be used in the research of autoimmune diseases (such as rheumatoid arthritis, psoriasis) and organ transplantation anti-rejection .
Cat. No.: HY-NP153
Synonyms: LTL (Biotinylated)
Cat. No.: HY-E70856
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PKCθ is a member of the Ca 2+-independent PKC subfamily. PKCθ plays an important role in T cell activation. PKCθ is also required for the survival of activated peripheral T lymphocytes. PKCθ Recombinant Human Active Protein Kinase is a recombinant PKCθ protein that can be used to study PKCθ-related functions .
Cat. No.: HY-12355R
CAS No.: 1230487-00-9
Synonyms: BAF-312 (Standard)
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Siponimod (BAF-312) (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
Cat. No.: HY-14977
CAS No.: 840523-39-9
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CS-0777-P, the phosphorylated form of CS-0777, acts as a potent and selective modulator of the S1P receptor-1 (S1P1). It exhibits approximately 320-fold higher agonist activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. In pharmacological studies, CS-0777-P demonstrated significant effects in vitro as an S1P1 and S1P3 agonist, leading to lowered peripheral blood lymphocyte counts and suppressive effects on experimental autoimmune encephalomyelitis (EAE) in rats. Pharmacokinetic studies in rats revealed rapid lymphocyte count reductions following oral administration, making CS-0777 a promising candidate currently undergoing clinical trials for the treatment of multiple sclerosis (MS) .
Cat. No.: HY-P990197
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Cat. No.: HY-W010553
CAS No.: 14400-67-0
Synonyms: 2,5-Dimethyl-2,3-dihydrofuran-3-one
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2,5-Dimethyl-3 (2H)-furanone (2,5-dimethyl-2,3-dihydrofuran-3-one) is an α,β-unsaturated 3 (2H)-furanone flavoring substance. 2,5-Dimethyl-3 (2H)-furanone does not show mutagenic activity in S. typhimurium .
Cat. No.: HY-W012813
CAS No.: 1193-79-9
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Cat. No.: HY-P5058
CAS No.: 193139-41-2
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Cat. No.: HY-133608
CAS No.: 16766-31-7
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4,6-Dichloroguaiacol induces biochemical and morphological changes in human peripheral blood lymphocytes in vitro .
Cat. No.: HY-137200
CAS No.: 41515-13-3
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N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes .
Cat. No.: HY-50692
CAS No.: 635701-59-6
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CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC50 of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant .
Cat. No.: HY-125881
CAS No.: 1228580-11-7
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ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile .
Cat. No.: HY-144126
CAS No.: 2760666-20-2
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S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS) .
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Alkaloids other families Monophenols Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
