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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
75 Results for "
PsA
" in MedChemExpress (MCE) Product Catalog:
Products (75)
75 Results for "PsA" in MCE Product Catalog:
Cat. No.: HY-RS11202
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PROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for PROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-155644
CAS No.: 2921602-31-3
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ROS inducer 1 (compound I29) is a fungicide, with EC50 against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops .
Cat. No.: HY-179123
CAS No.: 2757513-79-2
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ZC9 is a androgen receptor (AR) molecular glue degrader. ZC9 directly binds to AR and inhibits Dihydrotestosterone-induced nuclear translocation of AR. ZC9 promotes AR degradation via the ubiquitin-proteasome system and suppresses AR transcriptional activity. ZC9 significantly decreases the mRNA levels of other AR downstream genes, including PSA, TMPRSS2, and PMEPA1. ZC9 promotes Apoptosis. ZC9 exhibits anticancer activity against prostate cancer .
Cat. No.: HY-174391
CAS No.: 1790308-86-9
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AR antagonist 15 is an orally active androgen receptor (AR) antagonist with the IC50 of 97 nM for ART787A. AR antagonist 15 disrupts AR nuclear translocation, hinders AR homodimerization, and suppresses transcription of AR-regulated genes by competitive binding to the ligand binding pocket. AR antagonist 15 can significantly lower the prostate-specific antigen (PSA) level. AR antagonist 15 induces apoptosis by reducing the expression of apoptosis pathway related proteins. AR antagonist 15 can be used for the research of prostate cancer.
Cat. No.: HY-158410
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PSA-IN-1 (compound 19) is a puromycin sensitive aminopeptidase (PSA) inhibitor with IC50 at 7 nM. PSA-IN-1 has analgesic activity .
Cat. No.: HY-161688
CAS No.: 2323571-16-8
HDAC-IN-73 (compound P-503) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-73 shows IC50s values of 0.17, 0.49 µM for HDAC1 and HDAC6, respectively. Notably, HDAC-IN-73's inhibitory potency against HDAC6 is heightened, exhibiting a 9-fold greater efficacy than PsA (HY-N2150) (IC50=3.9 μM). HDAC-IN-73 shows potent antiproliferative activity, induces apoptosis, and causes cell cycle arrest at G2 / M phase. HDAC-IN-73 has the potential to be used for the research of cancer such as colon cancer .
Cat. No.: HY-170820
CAS No.: 3006788-11-7
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Molecular Glues Eukaryotic Release Factor (eRF) Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc
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XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-NP0185
Synonyms: PsA (Biotinylated)
Cat. No.: HY-NP002N
Synonyms: Pigeon Serum Albumin
Cat. No.: HY-106195
CAS No.: 207395-85-5
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L 377202 is a peptide-drug conjugate (PDC). L 377202 consists of Doxorubicin (HY-15142A) and a prostate-specific antigen (PSA)-hydrolyzable peptide. L 377202 demonstrates strong inhibitory effects on PSA-secreting prostate cancer cells. L 377202 is promising for research of prostate cancer .
Cat. No.: HY-RS09479
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NPEPPS Human Pre-designed siRNA Set A contains three designed siRNAs for NPEPPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17842
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Psat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07381
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KLK3 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10643
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PLAG1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLAG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-114246
CAS No.: 1351185-54-0
Synonyms: ONC1-13B
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Varilutamide (ONC1-13B) is an orally active androgen receptor (AR) inhibitor. Varilutamide shows a rat AR IC50 of 7.9 μM, inhibits DHT-stimulated PSA expression and prostate cancer cell proliferation, suppresses tumor growth and PSA expression and weakly induces lower CYP3A activity. Varilutamide can be used for the research of castration-resistant prostate cancer and prostate cancer .
Cat. No.: HY-RS11270
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PSAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for PSAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N8856
CAS No.: 1092952-64-1
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Campylotropis hirtella (Franch.) Schindl. Coumarins Leguminosae Extract Phenylpropanoids Plants
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DNA, 5'-GGGCGGGGCGGACGAGACAGTAAGGGCTGTGGGTGTGGTG-3', sodium salt
Cat. No.: HY-160046
Cat. No.: HY-N10280
CAS No.: 2701570-79-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
