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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
TACE
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "TACE" in MCE Product Catalog:
Cat. No.: HY-115351
CAS No.: 212609-68-2
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GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis .
Cat. No.: HY-118734
CAS No.: 478911-60-3
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IK-862 is a selective inhibitor of TACE .
Cat. No.: HY-P5970
CAS No.: 396716-14-6
Synonyms: TACE Substrate
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Cat. No.: HY-153504
CAS No.: 1219812-22-2
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TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research .
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EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation .
Cat. No.: HY-119307R
CAS No.: 287405-51-0
Synonyms: TMI-005 (Standard)
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Apratastat (Standard) is the analytical standard of Apratastat. This product is intended for research and analytical applications. Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-α. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC) . Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-RS00273
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Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00272
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Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-123736
CAS No.: 219613-02-2
Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor .
Cat. No.: HY-110046
CAS No.: 1188890-36-9
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .
Cat. No.: HY-100211A
CAS No.: 689284-12-6
Synonyms: (R)-TNF Protease Inhibitor 2
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
Cat. No.: HY-N0434R
CAS No.: 84687-42-3
Cat. No.: HY-115670R
CAS No.: 866924-39-2
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GW280264X (Standard) is the analytical standard of GW280264X (HY-115670). This product is intended for research and analytical applications. GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .
Cat. No.: HY-108647R
CAS No.: 321351-00-2
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EO 1428 (Standard) is the analytical standard of EO 1428 (HY-108647). This product is intended for research and analytical applications. EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation .
Cat. No.: HY-P702499
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ADAM17; Snake Venom-Like Protease; Prev. TACE; ADAM Metallopeptidase Domain 18; CSVP; Uncharacterized Protein ADAM17; Disintegrin And Metalloproteinase Domain-Containing Protein 17; TNF-Alpha Converting Enzyme; TNF-Alpha Convertase; CD156b Antigen; CD156B; ADAM17 Protein; Tumor Necrosis Factor, Alpha, Converting Enzyme; ADAM 17; A Disintegrin And Metalloproteinase 17; HYPT16; Cartilage Snake Venom-Like Protease; NISBD1; TNF-Alpha Convertase Enzyme; NISBD; TNF-Alpha-Converting Enzyme; ADAM Metallopeptidase Domain 17; ADAM18
Species:
Human
Source:
CHO
Cat. No.: HY-100211R
CAS No.: 187034-31-7
Synonyms: TNF Protease Inhibitor 2 (Standard)
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TAPI-2 (Standard) is the analytical standard of TAPI-2 (HY-100211). This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
Cat. No.: HY-184087
CAS No.: 205807-59-6
Synonyms: TNF484
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PKF 242-484 (TNF484) is an orally active dual inhibitor of TACE/MMPs, with Ki values of 3.6, 0.1, 0.9, 1, and 4.5 nM against hMMP-1, hMMP-2, hMMP-3, hMMP-9, and hMMP-13, respectively. PKF 242-484 inhibits the enzymatic activities of MMPs and ADAM17, reduces the release of TNF-α, suppresses the proliferation, migration and invasion of cancer cells, and regulates inflammatory cell infiltration and cytokine production. PKF 242-484 can be used in studies related to airway inflammatory diseases such as asthma and chronic obstructive pulmonary disease, intestinal ischemia-reperfusion injury, epilepsy-induced neuronal damage, and hepatocellular carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
