212609-68-2
212609-68-2
Chemical Structure
GW-3333
- CAS No.: 212609-68-2
- Formula:C22H36N4O4
- Molecular Weight:420.55
IUPAC Name: (2R,3S)-3-(N-hydroxyformamido)-2-isobutyl-4-methyl-N-((2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl)pentanamide
InChIKey: SMZPWUUYPYYHIV-HNJRGHQBSA-N
SMILES: CC[C@@H]([C@H](NC([C@@H]([C@@H](N(O)C=O)C(C)C)CC(C)C)=O)C(NC1=CC=CC=N1)=O)C
Biological Activity: GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis[1][2].
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GW-3333 | GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis. | |||||||||||||||||||||
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References
- [1]. Conway JG, et, al. Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases. J Pharmacol Exp Ther. 2001 Sep;298(3):900-8. [Content Brief]
- [2]. Doggrell SA. TACE inhibition: a new approach to treating inflammation. Expert Opin Investig Drugs. 2002 Jul;11(7):1003-6. [Content Brief]
