TACE inhibition: a new approach to treating inflammation

  • Expert Opin Investig Drugs. 2002 Jul;11(7):1003-6. doi: 10.1517/13543784.11.7.1003.
Sheila A Doggrell  1
Affiliations
  • 1. Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia. [email protected]
PMID: 12084010 DOI: 10.1517/13543784.11.7.1003
Abstract

Clinical trials showing the benefits of reducing the effects of TNF- alpha in rheumatoid arthritis have highlighted the key role of the cytokine TNF- alpha in this inflammatory condition. A new approach to reducing the effects of TNF- alpha is to decrease its synthesis by inhibiting TNF- alpha converting enzyme with GW3333. In rat models of arthritis, GW3333 has some beneficial effects. Further longer-term studies of GW3333 in animal models are required to determine whether its benefit is maintained. TACE inhibition may represent a new approach to treating inflammation.

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