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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
mt1
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "mt1" in MCE Product Catalog:
Target:
Research Areas:
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively [1].
Cat. No.: HY-107628
CAS No.: 220339-00-4
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N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses [1] .
Cat. No.: HY-A0014S
CAS No.: 1134159-63-9
Synonyms: TAK-375-d5
Synonyms: 2-Phenylmelatonin
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UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4 [1] .
Cat. No.: HY-17038S
CAS No.: 1079389-42-6
Synonyms: S-20098-d6
Cat. No.: HY-106136
CAS No.: 118702-11-7
Synonyms: PD-6735; LY-156735
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TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment [1] .
Cat. No.: HY-P10775
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Cat. No.: HY-17038S2
CAS No.: 1079389-38-0
Synonyms: S-20098-d3
Cat. No.: HY-147542
CAS No.: 2411150-76-8
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Melatonin receptor agonist 1 (compound 20c) is a potent melatonin receptor (MT) agonist, with Ki values of 108 nM (MT2) and 1140 nM (MT1) [1].
Cat. No.: HY-P10775A
Cat. No.: HY-116046
CAS No.: 170729-12-1
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GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR 196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice [1].
Cat. No.: HY-17038R
CAS No.: 138112-76-2
Synonyms: S-20098 (Standard)
Category:
Cat. No.: HY-119010
CAS No.: 753502-19-1
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UCM 549 is a melatonin MT2 receptor inverse agonist and a MT1 receptor antagonist [1].
Cat. No.: HY-17038S1
CAS No.: 1079389-44-8
Synonyms: S-20098-d4
Cat. No.: HY-133112
CAS No.: 166527-00-0
Synonyms: 3-Hydroxy-7-desmethyl agomelatine
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7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine [1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist [1] .
Cat. No.: HY-A0014R
CAS No.: 196597-26-9
Synonyms: TAK-375 (Standard)
Research Areas:
Ramelteon (Standard) is the analytical standard of Ramelteon. This product is intended for research and analytical applications. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation [1] .
Cat. No.: HY-14803R
CAS No.: 609799-22-6
Synonyms: BMS-214778 (Standard); VEC-162 (Standard)
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Tasimelteon (Standard) is the analytical standard of Tasimelteon. This product is intended for research and analytical applications. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [1] .
Cat. No.: HY-131947
CAS No.: 343263-95-6
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DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively [1].
Cat. No.: HY-101176R
CAS No.: 93515-00-5
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2-Iodomelatonin (Standard) is the analytical standard of 2-Iodomelatonin. This product is intended for research and analytical applications. 2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 ?over MT2 [1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
