132418-03-2
132418-03-2
Chemical Structure
IpOHA
- CAS No.: 132418-03-2
- Formula:C5H9NO4
- Molecular Weight:147.13
IUPAC Name: 2-(hydroxy(isopropyl)amino)-2-oxoacetic acid
InChIKey: QVIOSGUKMDGWNN-UHFFFAOYSA-N
SMILES: O=C(C(N(C(C)C)O)=O)O
Biological Activity: IpOHA is a ketol-acid reductoisomerase (KARI) inhibitor with a Kd of 22 pM. IpOHA forms a spinach KARI-magnesium-NADPH complex. IpOHA binds bacterial KARI faster than plant KARI and inhibits the growth of E. coli and M. tuberculosis. IpOHA can be used in research related to infection by Escherichia coli and Mycobacterium tuberculosis[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IpOHA | 98.61% | IpOHA is a ketol-acid reductoisomerase (KARI) inhibitor with a Kd of 22 pM. IpOHA forms a spinach KARI-magnesium-NADPH complex. IpOHA binds bacterial KARI faster than plant KARI and inhibits the growth of E. coli and M. tuberculosis. IpOHA can be used in research related to infection by Escherichia coli and Mycobacterium tuberculosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-121159Alanopine -
Similarity Score 0.74
HY-W141928N-Isobutyrylglycine -
Similarity Score 0.73
HY-W686479N-Oxalyl-L-alanine -
Similarity Score 0.73
HY-W004066Ac-Ala-OH -
Similarity Score 0.73
HY-W012713Ac-D-Ala-OH -
Similarity Score 0.72
HY-P4355D-Ala-Ala -
Similarity Score 0.72
HY-W010162RH-Ala-Ala-OH (Standard) -
Similarity Score 0.72
HY-W0154492-(2-Aminopropanamido)propanoic acid -
Similarity Score 0.72
HY-W015450RD-Ala-D-Ala (Standard) -
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References
- [1]. Wong SH, et al. Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of molecular biology. 2012 Dec 07;424(3-4):168-79.
- [2]. Kandale A, et al. Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry. 2021 Jan 29;64(3):1670-84. [Content Brief]
- [3]. Patel K M. Ketol-acid reductoisomerase as a target for antimicrobial drug discovery[J]. 2021. [Content Brief]
- [4]. Krishna VS, et al. Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads. Journal of computer-aided molecular design. 2019 Mar;33(3):357-366.
- [5]. Grandoni JA, et al. Inhibitors of branched-chain amino acid biosynthesis as potential antituberculosis agents. The Journal of antimicrobial chemotherapy. 1998 Oct;42(4):475-82.
