48 Results for "

recurrent

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "recurrent" in MCE Product Catalog:

Cat. No.: HY-168979
CAS No.: 1606995-47-4
Synonyms: NMS-03305293; NMS-293
Target:  

PARP

Research Areas:  

Cancer

Itareparib (NMS-03305293; NMS-293) is a selective, orally active, blood-brain barrier-permeable PARP1 inhibitor with an IC50 < 0.01 μM. Itareparib does not form PARP1-DNA trapping complexes, avoids PARP-DNA "retention", reduces PAR levels and inhibits the growth of homologous recombination-deficient cells. Itareparib can be used in research on advanced solid tumors, recurrent gliomas and other conditions .
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Cat. No.: HY-14743
CAS No.: 229305-39-9
Purity:  98.04%
Synonyms: SCV 07; Gamma-D-glutamyl-L-tryptophan
Target:  

Bacterial STAT

Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
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Cat. No.: HY-P991525
CAS No.: 2923542-55-4

Target:  

Fc Receptor (FcR)

Research Areas:  

Cancer

2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8 + T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma .
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Cat. No.: HY-U00161
CAS No.: 22298-29-9
Research Areas:  

Inflammation/Immunology

Betamethasone 17-benzoate is a representative steroid, which can be used in the treatment of recurrent aphothous ulcers (RAU).
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Cat. No.: HY-B1402G
CAS No.: 2203-97-6
Synonyms: Hydrocortisone 21-hemisuccinate (GMP)
Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC50 values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers . .
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Cat. No.: HY-125555
CAS No.: 133-60-8
Target:  

Bacterial

Research Areas:  

Infection Neurological Disease

Azosulfamide has an anticonvulsant effect and can be used for research of epilepsy. Azosulfamide is active against recurrent tetanus .
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Cat. No.: HY-B1630
CAS No.: 130-80-3
Target:  

Estrogen Receptor/ERR

Research Areas:  

Cancer

Stilbestrol dipropionate is an estrogen-like compound with hormone suppressive activity for recurrent prostate cancer. Stilbestrol dipropionate can be used to suppress diseases associated with estrogen deficiency .
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Cat. No.: HY-128938A
Purity:  98.04%
Target:  

ADC Linkers

Research Areas:  

Cancer

EC1167 hydrochloride is the linker for EC1169. EC1169 is prostate-specific membrane antigen targeting-tubulysin conjugate. EC1169 hydrochloride has the potential to treat recurrent metastatic, castration-resistant prostate cancer (MCRPC) .
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Cat. No.: HY-128938
CAS No.: 1610414-00-0
Target:  

ADC Linkers

Research Areas:  

Cancer

EC1167 is the linker for EC1169. EC1169 is prostate-specific membrane antigen targeting-tubulysin conjugate. EC1169 has the potential to treat recurrent metastatic, castration-resistant prostate cancer (MCRPC) .
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Cat. No.: HY-115499
CAS No.: 1310540-32-9
Target:  

Drug Intermediate

Research Areas:  

Cancer

MPC-0767 is an orally active prodrug of Hsp90 inhibitor. MPC-0767 undergoes rapid biotransformation to the parent Hsp90 inhibitor MPC-3100 via enzyme-mediated luminal cleavage. MPC-0767 is applicable to the research of refractory and recurrent cancers .
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Cat. No.: HY-123400A
CAS No.: 133276-52-5
Synonyms: iso-DTTX30; iso-DT-TX 30 SE
Research Areas:  

Cardiovascular Disease

Iso-Samixogrel (iso-DTTX30) is a combined thromboxane A2 receptor blocker and thromboxane synthetase inhibitor that exhibits potent antithrombotic activity. Iso-Samixogrel effectively eliminates recurrent arterial thrombus formation and inhibits collagen-induced platelet aggregation ex vivo. Iso-Samixogrel also prolongs sublingual bleeding time, demonstrating its biological efficacy in managing thrombosis.
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Cat. No.: HY-172768
CAS No.: 2930140-57-9
Target:  

Bacterial

Research Areas:  

Infection

SCUT1-2 is a bifunctional antibacterial agent with good oral bioavailability in mice (F=56.8%). SCUT1-2 can kill the vegetative cells of C. difficile with a MIC of 0.06-0.50 μg/mL, and inhibit spore germination in vitro. SCUT1-2 could alleviate the symptoms of weight loss and diarrhea in mice caused by C. difficile infection (CDI) and prevent recurrent CDI .
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Cat. No.: HY-B0727R
CAS No.: 2152-44-5
Synonyms: Betamethasone 17-valerate (Standard)
Betamethasone valerate (Standard) is the analytical standard of Betamethasone valerate. This product is intended for research and analytical applications. Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone ( 3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively .
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Cat. No.: HY-127004
CAS No.: 140944-30-5
Synonyms: RGH-5002
Target:  

Sodium Channel

Research Areas:  

Others

Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis .
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Cat. No.: HY-14743A
CAS No.: 2828433-07-2
Synonyms: SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA
Target:  

Bacterial STAT

Golotimod TFA (SCV 07 TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod TFA (SCV 07 TFA) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod TFA (SCV 07 TFA) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
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Cat. No.: HY-14743R
CAS No.: 229305-39-9
Synonyms: SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
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Cat. No.: HY-P990082
CAS No.: 1610010-57-5
Synonyms: APX-003; BD-0801

Target:  

VEGFR

Research Areas:  

Cardiovascular Disease Cancer

Suvemcitug (APX-003) is a selective humanized rabbit monoclonal IgG1 (κ) anti-VEGF antibody. Suvemcitug inhibits the binding of VEGF to purified VEGFR1 (IC50 = 21.0 ng/mL) and VEGFR2 (IC50 = 275.4 ng/mL). Suvemcitug suppresses tumor angiogenesis, tumor growth and metastasis. Suvemcitug is applicable to research related to epithelial ovarian cancer, fallopian tube cancer and primary peritoneal cancer .
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Cat. No.: HY-W747550A
CAS No.: 59386-02-6
Target:  

Others

Research Areas:  

Endocrinology

(3R,4S)-Hexestrol dipropionate (hexestrol dipropionate) is a synthetic estrogen with uterine contraction-relieving activity. (3R,4S)-Hexestrol dipropionate can be used for the research of diseases such as recurrent preterm birth and spontaneous abortion .
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Cat. No.: HY-Z11709
CAS No.: 1160974-39-9
13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma .
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Cat. No.: HY-10587R
CAS No.: 935693-62-2
BIX-01294 (Standard) is the analytical standard of BIX-01294 (HY-10587). This product is intended for research and analytical applications. BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells .
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