MPC-0767
MPC-0767 is an orally active prodrug of Hsp90 inhibitor. MPC-0767 undergoes rapid biotransformation to the parent Hsp90 inhibitor MPC-3100 via enzyme-mediated luminal cleavage. MPC-0767 is applicable to the research of refractory and recurrent cancers.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1310540-32-9
- 화학식: C26H36BrN7O9S2
- 분자량:734.64
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
In Vitro
MPC-0767 mesylate salt has a half-life of <2 min in mouse plasma, 300 min in monkey plasma, 149 min in human plasma, and 145 min in pH 7.4 phosphate buffer[1].
MPC-0767 mesylate salt has a half-life of <2 min in mouse liver microsomes and 2 min in human liver microsomes, with no difference observed between assays run with or without NADPH[1].
MPC-0767 mesylate salt is highly stable in simulated gastric fluid but undergoes rapid conversion in pancreatin-containing simulated intestinal fluid with a half-life of 22 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MPC-0767 mesylate salt (p.o.; 265 mg/kg) exhibits comparable efficacy in the N-87 xenograft tumor model, inducing a 46% reduction in tumor volume without causing body weight loss[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1310540-32-9
-
분자량 734.64
-
화학식 C26H36BrN7O9S2
-
SMILES
N[C@@H](C)C(O[C@@H](C)C(N1CCC(CCN2C(SC3=C(Br)C=C(OCO4)C4=C3)=NC5=C(N)N=CN=C25)CC1)=O)=O.CS(=O)(O)=O.[H]O[H]
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Kim SH, et al. Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100. Bioorganic & medicinal chemistry letters. 2015 Nov 15;25(22):5254-7. [Content Brief]
[2]. Gomez-Monterrey I, et al. Heat shock protein 90 inhibitors as therapeutic agents. Recent patents on anti-cancer drug discovery. 2012 Sep;7(3):313-36. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPC-0767 Related Classifications
HY-115499 Related Classifications
Powered by Bioz